Progressive multifocal leukoencephalopathy in patients with chronic liver disease successfully treated with pembrolizumab

Jeantin, Lina; Shor, Natalia; Coustans, Marc; Roos-Weil, Damien; Quintin-Roué, Isabelle; Bellanger, Agnès; Le Garff-Tavernier, Magali; Ben Jemaa, Rahma; Thabut, Dominique; Pourcher, Valérie; Weiss, Nicolas

doi:10.1007/s00415-023-12163-6

Cited by 1 publication

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References 10 publications

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“…Also, PML has possibly been evident in a case with Coronavirus Disease 2019 (COVID-19) as well as in a patient with Hepatitis B virus-induced CD4 lymphocytopenia, while the disease may occur in the context of systemic sarcoidosis without immunosuppression in which it can even be the first sign, and it can initially be mistaken for neurosarcoidosis or other complications of sarcoidosis [63][64][65]. Also, divergent cases of chronic physiologic diseases/disorders under various therapies can spontaneously express PML, like Chronic Liver Disease (CLD), Chronic Kidney Disease (CKD) and other issues [66,67].…”

Section: Epidemiology Of Jcpyv and Pmlmentioning

confidence: 99%

John Cunningham Virus and Progressive Multifocal Leukoencephalopathy: A Falsely Played Diagnosis

Mouliou

2024

Diseases

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Progressive Multifocal Leukoencephalopathy (PML) is a possibly fatal demyelinating disease and John Cunningham Polyomavirus (JCPyV) is believed to cause this condition. The so-called JCPyV was initially reported in lymphoma and Human Immunodeficiency Virus (HIV) cases, whereas nowadays, its incidence is increasing in Multiple Sclerosis (MS) cases treated with natalizumab (Tysabri). However, there are conflicting literature data on its pathology and diagnosis, whereas some misdiagnosed reports exist, giving rise to further questions towards the topic. In reality, the so-called PML and the supposed JCPyV are not what they seem to be. In addition, novel and more frequent PML-like conditions may be reported, especially after the Coronavirus Disease 2019 (COVID-19) pandemic.

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Section: Epidemiology Of Jcpyv and Pmlmentioning

confidence: 99%

John Cunningham Virus and Progressive Multifocal Leukoencephalopathy: A Falsely Played Diagnosis

Mouliou

2024

Diseases

View full text Add to dashboard Cite

show abstract

Progressive multifocal leukoencephalopathy in patients with chronic liver disease successfully treated with pembrolizumab

Cited by 1 publication

References 10 publications

John Cunningham Virus and Progressive Multifocal Leukoencephalopathy: A Falsely Played Diagnosis

John Cunningham Virus and Progressive Multifocal Leukoencephalopathy: A Falsely Played Diagnosis

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