Progressive Malignant Degeneration of a Cystadenoma of the Pancreas

Probstein, J. G.

doi:10.1001/archsurg.1960.01300050005002

Cited by 20 publications

(6 citation statements)

References 11 publications

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“…Clinical, pathological, and molecular observations have established that a mucinous cystic neoplasm with mild dysplasia can progress to a mucinous cystic neoplasm with moderate dysplasia, and from there to mucinous cystic neoplasm with carcinoma in situ. Furthermore, it is clear that if left untreated, noninvasive mucinous cystic neoplasms can progress to invasive carcinoma . For example, molecular analyses have documented that the progression from mucinous cystic neoplasm with low‐grade dysplasia to mucinous cystic neoplasm with an associated invasive carcinoma is associated with the progressive accumulation of genetic alterations in cancer‐associated genes, including KRAS , TP53 , and SMAD4/DPC4 .…”

Section: Mucinous Cystic Neoplasmsmentioning

confidence: 99%

Clinical importance of precursor lesions in the pancreas

Hruban

Takaori

Canto

et al. 2007

J Hepatobiliary Pancreat Surg

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Three distinct noninvasive precursor lesions to invasive ductal adenocarcinoma of the pancreas have been described. These include the mucinous cystic neoplasm, intraductal papillary mucinous neoplasm, and pancreatic intraepithelial neoplasia. The early detection and treatment of these lesions can interrupt the progression of a curable noninvasive precursor to an almost uniformly deadly invasive cancer.

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Section: Mucinous Cystic Neoplasmsmentioning

confidence: 99%

Clinical importance of precursor lesions in the pancreas

Hruban

Takaori

Canto

et al. 2007

J Hepatobiliary Pancreat Surg

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“…The natural history of mucinous cystic tumor of the pancreas has been considered to indicate exceedingly slow growth, as judged by the relative lack of tendency to infiltrate adjacent tissues and organs, the good second chances for a complete resection even several years after the first operation, and the low likelihood of distant metastasis. 1,8,11,15 Nevertheless, there are few reports of the natural history of mucinous cystic tumor of the pancreas, because most neoplastic cystic lesions are resected at the time of diagnosis. The present patient was diagnosed as having mucinous cystadenoma on the basis of the histopathologic findings of the cyst wall biopsy specimen taken at the time of cystgastrostomy, but complete resection of the cystic mass was possible 11 years later.…”

Section: Discussionmentioning

confidence: 99%

Mucinous cystadenoma of the pancreas resected 11 years after cystgastrostomy

Masatsugu

Yamaguchi

Arima

et al. 2002

Journal of Gastroenterology

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There have been numerous reports that mucinous cystadenoma of the pancreas can transform to mucinous cystadenocarcinoma after cystenterostomy, but few authors have reported morphological changes long after cystenterostomy for mucinous cystadenoma. A 41-year-old Japanese woman had undergone cystgastrostomy at a nearby hospital 11 years before undergoing the treatment reported here. The preoperative diagnosis at the time of cystgastrostomy was a pancreatic cyst. At laparotomy a cyst, measuring 10cm in diameter, was found in the body and tail of the pancreas. The histopathological diagnosis of the cyst wall was mucinous cystadenoma of mild dysplasia. Computed tomography 10 years after the cystgastrostomy showed that the cyst had decreased in diameter from 10 cm to 5cm. Gastroscopy showed a scar at the cystgastrostomy site in the stomach. A complete resection of the mucinous cystadenoma was done, 11 years after the cystgastrostomy, because of the malignant potential. The resected specimen showed mucinous cystadenoma of mild dysplasia with structural and cellular atypia similar to that in the previous specimen. There was no malignant change. The patient was discharged after an uneventful postoperative course and no recurrence has been evident for 6 months to date. This case showed imaging and histopathological evidence of the slow-growing nature of mucinous cystadenoma of the pancreas.

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“…However, cystadenocarcinoma may arise from preexisting cystadenoma (Glenner and Mallory, 1956;Cornes and Azzopardi, 1959). The evidence of this is: (1) Similarity of sites of origin and similar age and sex distribution (Probstein and Blumenthal, 1960). (2) The existence of benign and malignant areas in the same tumor with transition between the two (Glenner and Mallory, 1956).…”

Section: Commentmentioning

confidence: 99%

“…(2) The existence of benign and malignant areas in the same tumor with transition between the two (Glenner and Mallory, 1956). (3) The development of cystadenocarcinoma in a benign cystadenoma, followed for several years (Lichtenstein, 1934;Probstein and Blumenthal, 1960). stressed, as their treatment differs markedly from that of the more common cysts of the pancreas (e.g., pseudocysts, retention cysts, etc.).…”

Section: The Incidence Sex and Age Distribution And Clinical Featurmentioning

confidence: 99%

Cystadenoma and cystadenocarcinoma of the pancreas

Barbee

Demello

Grage

1976

Journal of Surgical Oncology

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Cystadenoma and cystadenocarcinoma comprise the majority of the true neoplastic cysts of the pancreas. Five cystadenomas and two cystadenocarcinomas of the pancreas were found in a review of the clinical records of the University of Minnesota Hospitals and the Minneapolis Veterans Administration Hospital. The report of these cases serves to review the clinical and pathological features of these neoplasms. These rare neoplastic cysts occur predominantly in women and are not associated with a history of trauma, alcoholism, or pancreatitis. They produce symptoms by compression of neighboring organs and are slow growing, often attaining large size. With complete excision the results of surgical treatment are usually good.

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Progressive Malignant Degeneration of a Cystadenoma of the Pancreas

Cited by 20 publications

References 11 publications

Clinical importance of precursor lesions in the pancreas

Clinical importance of precursor lesions in the pancreas

Mucinous cystadenoma of the pancreas resected 11 years after cystgastrostomy

Cystadenoma and cystadenocarcinoma of the pancreas

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