Progressive Hemiparesis in Frontal Lobe Degeneration

Schmidtke, Klaus; Hiersemenzel, Lutz-Peter

doi:10.1159/000113182

Cited by 8 publications

(4 citation statements)

References 38 publications

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“…Extrapyramidal features were constant, and hemiparesis was relatively frequent, although clinically difficult to link with extrapyramidal or pyramidal dysfunction, as recently discussed by Schmidtke and Hiersemenzel [18]. Difficulty Pasquier/Lebert/Lavenu/Guillaume with swallowing is frequent, and possibly fearful because of the inappropriate hyperorality.…”

Section: Discussionmentioning

confidence: 90%

The Clinical Picture of Frontotemporal Dementia: Diagnosis and Follow-Up

Pasquier

Lebert

Lavenu

et al. 1999

Dement Geriatr Cogn Disord

103

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Frontotemporal dementia (FTD) was diagnosed in 74 outpatients with a standardized assessment including neuropsychological tests, behavioural scale, structural and functional imaging. Clinical characteristics were consistent with the literature data. The cohort was followed for 2–6 years to determine the reliable variable for evaluating the progression of FTD. Every fourth patient died after a mean duration of 7 years. At first, FTD manifests itself in behavioural changes with relatively stable global cognition although language, verbal fluency and memory tests were reliable tools to follow the progression of the disease. Below 18 of Mini-Mental State Examination, mutism and apathy prevented from neuropsychological testing within the next 6 months. Behavioural disorders evolved with time but restlessness and hyperorality were long-lasting. Imaging showed the progression of a consistent pattern of anterior abnormalities with frequent leukoaraiosis.

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Section: Discussionmentioning

confidence: 90%

The Clinical Picture of Frontotemporal Dementia: Diagnosis and Follow-Up

Pasquier

Lebert

Lavenu

et al. 1999

Dement Geriatr Cogn Disord

103

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“…Therefore the value of introducing such a new terminology can be seriously questioned. However, we agree [20][21][22][23] (III) Without motor disorders/with motor disorders (a) Motor neuron disease [24] (b) Primary lateral sclerosis (c) Parkinsonism (d) Hemiparesis [25] (e) A combination of motor disorders Different axes for clinical description of frontotemporal degeneration. On the first axis, the presence or absence of dementia is determined.…”

Section: Discussionmentioning

confidence: 51%

Progressive Dysarthria

Santens¹,

J²,

Foncke³

et al. 1999

Dement Geriatr Cogn Disord

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Two patients presenting with progressive dysarthria as the single initial manifestation of a neurodegenerative condition are described. The nature of the dysarthria as well as the additional symptoms that developed in the course of the disorder are very different in these two cases. Nevertheless, neuroimaging findings are strikingly similar and suggest bilateral involvement of posterior inferior frontal lobe structures, mainly in the dominant cerebral hemisphere. The clinical syndrome of these patients can therefore be considered an example of frontotemporal degeneration presenting without dementia or comportmental alteration, at least in the early stages. This broadens the clinical spectrum of frontotemporal degeneration and demonstrates the need for a syndromal subclassification of this nosological entity.

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“…It is postulated that dura lymphatic stasis accompanying subdural haematoma leads to the accumulation of toxic metabolites from neuroparenchymal tissue. [8] It is hoped that future research will provide data on outcomes in patients with combined degenerative and non-degenerative dementia while unravelling the neurobiological underpinnings.…”

Section: Discussionmentioning

confidence: 99%

Pick’s disease and subdural haematoma: A diagnostic red herring

Adebayo¹,

Taiwo²,

Bakshi³

et al. 2019

Ann Health Res

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Frontotemporal dementia (FTD), otherwise known as Pick’s disease, is a clinically heterogeneous group of sporadic and familial neurodegenerative diseases. These conditions are characterized by dementia, behavioural and language dysfunction and loss of executive skills resulting from the degeneration of the frontal and temporal lobes. Although reversible causes of dementia are always sought during the evaluation of patients with progressive cognitive decline, the occurrence of a reversible aetiology may distract from evaluating for neurodegenerative causes of dementia. This report is about a 66-year old man with features of FTD and superimposed chronic subdural haematoma.

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Progressive Hemiparesis in Frontal Lobe Degeneration

Cited by 8 publications

References 38 publications

The Clinical Picture of Frontotemporal Dementia: Diagnosis and Follow-Up

The Clinical Picture of Frontotemporal Dementia: Diagnosis and Follow-Up

Progressive Dysarthria

Pick’s disease and subdural haematoma: A diagnostic red herring

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