Exterior columns are highly susceptible to structural damage in cases of blast attacks, and its failure may lead to a progressive collapse of the entire structure. In this study, a three-dimensional nonlinear dynamic analysis was carried out on a 10-Storey reinforced concrete office building. The building was designed according to ACI 318, then its exterior columns were subjected to blast loading threat. The computational program used is Extreme Loading for Structures software, which is based on the applied element method (AEM).The AEM can estimate the structural behavior from the elastic stage through cracking, large displacement, complete elements separation, and eventually collapse. In this study, an exterior column is analyzed under different weights of (TNT) detonation charges concerning different standoff distances, the behavior of the columns is evaluated according to UFC 3-340-02 and PDC-TR 06-08. Analysis trials are carried out to estimate a safe and economical column design that can withstand a predefined charge weight and standoff distance.