Progressive Cicatrizing Endotheliitis Associated with Leucocytoclastic Vasculitis and Crohn Disease

Rocha, Guillermo; Mednick, Zale

doi:10.3109/09273948.2012.761241

Cited by 1 publication

(1 citation statement)

References 13 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 Troncoso et al reported some diverse corneal manifestations of IBD in a review paper. 18 Corneal impairments can occur in diverse corneal layers: epithelial, deep stromal, or endothelial, [19][20][21][22][23][24][25][26] but it is important to remember that some corneal findings are rather unusual and that there are cases associated with other inflammatory disorders. Diverse diagnostic tools : flattest meridian; K2: steepest meridian; K m : mean corneal power; R min : minimum radius of the cornea; ACA: anterior chamber; K max : maximal keratometry; CV: corneal volume; ACV: anterior chamber volume; ACD: anterior chamber depth; ACA: anterior chamber angle width; D: diopter Seminars in Ophthalmology 547 have already been used to examine corneal impairments related to IBD, such as videokeratography 27 or confocal microscopy 28 ; nevertheless, detailed corneal and anterior segment parameters have not been investigated thus far.…”

Section: Discussionmentioning

confidence: 99%

Corneal Manifestations of Inflammatory Bowel Disease

Czompa

Barta

Ziad

et al. 2019

Seminars in Ophthalmology

View full text Add to dashboard Cite

Purpose: To evaluate detailed corneal parameters of inflammatory bowel disease (IBD) patients, including Crohn's disease (CD) and ulcerative colitis (UC) patients, and to assess associations between anterior segment values and other clinical variables. Methods: This prospective cross-sectional case-control study at a tertiary referral center included 30 CD patients, 36 UC patients and 80 age-and gender-matched controls with no ocular symptoms or ocular surface disorders. All study participants underwent a comprehensive ophthalmological evaluation with special interest in dry eye disease (DED). Corneal parameters were evaluated by Pentacam. Results: The mean age of CD patients, UC patients, and controls was 45.80 ± 11.55 years, 52.00 ± 16.05, and 50.68 ± 14.62, respectively. The average disease duration was 12.72 ± 5.83 years for CD patients and 15.94 ± 10.09 years for UC patients. All pachymetric (center, apex and thinnest) and corneal volume (CV) measurements were significantly decreased, while anterior chamber angle width (ACA) values were significantly increased on both sides in all IBD patients compared to those in controls (p < .05). In addition, several anterior segment parameters were altered unilaterally in CD or UC patients. Negative correlations were found between corneal parameters and Schirmer I test values. Conclusions: Our investigations suggest that IBD patients have thinner corneas compared to that of controls. The coexistence of reduced tear quantity seems to have an additional impact on the thinning of the cornea in IBD patients. Early recognition of corneal impairments, a possible extraintestinal manifestation of IBD, should be included in the disease checkup to reduce vision-threatening developments.

show abstract