Progressive chronic calvarial osteomyelitis in rhino-orbital mucormycosis associated with COVID-19

Pott's puffy tumor: An unusual complication of rhino-orbito-cerebral mucormycosis

“…18 , 19 , 20 Significant cranial vault osteomyelitis secondary to ROCM was also seen, albeit less frequently. 7 , 8 , 9 , 12 , 13 , 21 , 22 However, presentation as PPT has been rarely described during either the pre-pandemic 6 or pandemic eras, 11 both publications being single case reports in adult patients.…”

Osteomyelitis following infection with SARS-CoV-2 (COVID-19): A mini-review

“…Of course, during this type of pandemic, the vaccine still plays a significant role in COVID-19 development and subsequently osteomyelitis. Considering the multi-organ failure following infection with COVID-19, it seems logical that any infection in the differential diagnosis should also include COVID-19 because it also affects the eyes, kidneys, lungs and other organs [13][14][15][16][17][18] .…”

Increase in mucormycosis hospitalizations in southeastern Brazil during the COVID-19 pandemic: a 2010-2021 time series

“…To date, five cases of CAM have been reported in Brazil, one in Manaus 10 , and four in São Paulo 9,11,12 . All patients had rhinocerebral infection, four had a previous diagnosis of diabetes, and three had severe COVID-19 requiring mechanical ventilation, with one death.…”

“…A published review of 80 CAM reports and case series also described rhinocerebral infections as the most common site of infection 4 . The authors highlighted that the COVID-19 pandemic poses a substantial risk for invasive fungal infections, especially because of the increased number of intensive care patients, long hospitalizations, antibiotic use, and systemic corticosteroids 8,11,12,14 . Additionally, corticosteroids were the only therapy with an impact on mortality in the first wave, and their prolonged use significantly altered glycemia in patients with diabetes.…”