Progressive Changes in the Retinal Nerve Fiber Layer in Patients with Multiple Sclerosis

“…Blumenthal et al [43] and Schuman et al [38] have reported similar results in their evaluations of glaucoma and healthy eyes, and the most accepted theory is that it is difficult to calculate the RNFL thickness in the nasal area using the current measurement algorithm [9,12], although Knighton and Qian [44] suggested that this problem is due to the angle of incidence of the illuminating beam, which makes the RNFL image on the nasal side dimmer.…”

Section: Discussionmentioning

confidence: 56%

“…Several studies report a correlation between axonal loss in the optic nerve of MS patients and the extent of functional disability [7,8,9], but the risk factors for increased axonal degeneration remain unclear. RNFL atrophy has been demonstrated in MS patients [10,11,12], with axonal loss being greater in patients who reported a previous episode of optic neuritis (ON) [7,12,13]. Given that optic nerve evaluation is used as an axonal damage biomarker in MS patients, it is important to determine which sectors or RNFL areas are preferentially affected by ON.…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Geometries Representing the Retinal Nerve Fiber Layer in Multiple Sclerosis, Optic Neuritis, and Healthy Eyes

García‐Martín

Calvo²,

Malvè³

et al. 2013

Ophthalmic Res

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Background: To represent and interpret the three-dimensional (3D) geometry and the distribution of the axonal damage to the retinal nerve fiber layer (RNFL) in patients with multiple sclerosis (MS) compared with healthy subjects. To analyze alterations in RNFL morphology in eyes of MS patients with or without previous episodes of optic neuritis (ON). Methods: MS patients (n = 122) and age-matched healthy subjects (n = 108) were enrolled. The Spectralis optical coherence tomography system was used to determine the circumpapillary RNFL thickness. The 768 RNFL thickness measurements were used to evaluate thickness measurements in patients with or without antecedent ON and to design a 3D reconstruction of the RNFL thickness representing the mechanobiologic tissue response to neurodegeneration caused by MS and ON episodes. Results: RNFL thickness was decreased in MS patients, and was higher in the MS group with previous ON. Statistical analysis and 3D RNFL reconstruction revealed greater damage to the ganglionar cells in the superonasal RNFL area (101.77 µm in MS vs. 125.47 µm in healthy subjects) and in the inferotemporal RNFL (119.05 µm in MS eyes and 149.26 µm in healthy eyes). Conclusions: The 3D representation of RNFL thickness based on measurements allows physicians to better observe damage in the temporal areas, especially in patients with previous ON.

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“…[15][16][17][18][19][20][21][22] MS eyes with a previous history of ON have significant loss of RNFL thickness compared with the eyes of healthy controls and clinically unaffected eyes in the patients with MS. 9,15,22,23 According to a review, Visual System in Relapsing-Remitting Multiple Sclerosis 3…”

Section: Discussionmentioning

confidence: 99%

Relationship between Structural and Functional Assessment of the Visual System in Mildly Disabled Relapsing-Remitting Multiple Sclerosis Patients

Huseyinoglu

Ekinci

Özben

et al. 2014

Neuro-Ophthalmology

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Studies that explored the anterior visual pathway in the patients with multiple sclerosis (MS) have demonstrated contradictory results about the correlation between structural and functional status of optic nerve and retina. We aimed to investigate the functional and structural findings in our cohort of mildly disabled relapsing-remitting MS patients. A total of 134 eyes (80 eyes of the patients with MS and 54 eyes of the control group) were investigated. Eyes of MS patients were divided into two groups-as eyes with history of optic neuritis (ON group) and without history of optic neuritis (NON group). Ophthalmological investigation including visual evoked potentials, standard automated perimetry, and optical coherence tomography were performed for all participants. Retinal and macular thicknesses were significantly decreased in ON and NON groups compared with controls. Also, visual evoked potential latencies and visual field loss were worse in the both MS groups compared with control group. We did not find any correlation between visual evoked potentials and retinal or macular thickness values but visual field parameters were correlated between retinal and macular layer loss in the NON group. According to our results and some previous studies, although both functional and structural changes were detected in patients with MS, functional status markers do not always show parallelism (or synchrony) with structural changes, especially in eyes with history of optic neuritis.

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Progressive Changes in the Retinal Nerve Fiber Layer in Patients with Multiple Sclerosis

Abstract: Axonal loss in the optic nerve of patients with MS is greater than that expected in healthy subjects, regardless of the presence of a previous optic neuritis.

Cited by 72 publications

References 25 publications

Color-Code Agreement Among Stratus, Cirrus, and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis With and Without Prior Optic Neuritis

Color-Code Agreement Among Stratus, Cirrus, and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis With and Without Prior Optic Neuritis

Three-Dimensional Geometries Representing the Retinal Nerve Fiber Layer in Multiple Sclerosis, Optic Neuritis, and Healthy Eyes

Relationship between Structural and Functional Assessment of the Visual System in Mildly Disabled Relapsing-Remitting Multiple Sclerosis Patients

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