Progressive Amusia and Aprosody

On the spatial organization of sound processing in the human temporal lobe: A meta-analysis

“…The failure to observe a right lateralization for music may be due to our restricted focus on the temporal lobe. Perhaps such lateralization arises primarily in frontal (Peretz et al, 1997;Yasui et al, 2009) and/or parietal regions (Confavreux et al, 1992).…”

“…A second traditional notion is that the lefthemisphere is specialized for the processing of speech or linguistically relevant sounds, whereas the right hemisphere is specialized for the processing of music. This notion arose from evidence that left hemisphere lesions (e.g., Wernicke's area in the posterior superior temporal cortex) disturb language functions (Wernicke, 1874), whereas right hemisphere lesions disturb musicality (Confavreux et al, 1992;Peretz et al, 1997).…”

Amusia as an early manifestation of frontotemporal dementia caused by a novel progranulin mutation

“…Acquired amusia has been described associated with focal cortical degeneration, particularly within the cognitive and behavioural manifestations of frontotemporal dementia [1,3,6]. We report herein a family with frontotemporal dementia caused by a novel progranulin gene mutation whose proband presented with impaired musical appreciation as an early symptom of the disease.…”

Amusia and musicogenic epilepsy

“…Clinical case studies have reported patients with ischemic [17,18], hemorrhagic [19], or degenerative [20] lesions of the right temporal lobe who developed disturbances of melody perception (amelodia). Sparr [15] recently described the case of isolated receptive amelodia in a highly accomplished musician due to an ischemic infarction of the right temporal lobe.…”