Progression to dementia in memory clinic patients without dementia

Köhler, Sebastian; Hamel, Renske; Sistermans, Nicole; Koene, Teddy; Pijnenburg, Yolande A.L.; Flier, Wiesje M. van der; Scheltens, Philip; Visser, Pieter Jelle; Aalten, Pauline; Verhey, Frans R.J.; Ramakers, Inez H.G.B.

doi:10.1212/wnl.0b013e3182a82536

Cited by 22 publications

(16 citation statements)

References 35 publications

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“…These relations are supported by neuroimaging findings showing that within MCI, those with intact functioning as measured by informant ratings (Pfeffer Functional Activities Questionnaire, FAQ) had greater hippocampal volumes as well as better performance on tests of auditory verbal memory and processing speed compared to those with moderate or severe FAQ ratings (Brown et al 2011). Consistent with this, episodic memory impairment in MCI has been associated with elevated risk for conversion to AD compared to other cognitive dysfunction (Aggarwal et al 2005;Luck et al 2011), although this is in contrast to findings by Kohler and colleagues showing non-amnestic MCI to have the highest risk of dementia, above that of amnestic subtypes (Kohler et al 2013).…”

Section: Cognitive Processes and Everyday Functioningmentioning

confidence: 52%

The Potential Utility of Eye Movements in the Detection and Characterization of Everyday Functional Difficulties in Mild Cognitive Impairment

Seligman

Giovannetti

2015

Neuropsychol Rev

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Mild cognitive impairment (MCI) refers to the intermediate period between the typical cognitive decline of normal aging and more severe decline associated with dementia, and it is associated with greater risk for progression to dementia. Research has suggested that functional abilities are compromised in MCI, but the degree of impairment and underlying mechanisms remain poorly understood. The development of sensitive measures to assess subtle functional decline poses a major challenge for characterizing functional limitations in MCI. Eye-tracking methodology has been used to describe visual processes in everyday, naturalistic action among healthy older adults as well as several case studies of severely impaired individuals, and it has successfully differentiated healthy older adults from those with MCI on specific visual tasks. These studies highlight the promise of eye-tracking technology as a method to characterize subtle functional decline in MCI. However, to date no studies have examined visual behaviors during completion of naturalistic tasks in MCI. This review describes the current understanding of functional ability in MCI, summarizes findings of eye-tracking studies in healthy individuals, severe impairment, and MCI, and presents future research directions to aid with early identification and prevention of functional decline in disorders of aging.

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Section: Cognitive Processes and Everyday Functioningmentioning

confidence: 52%

The Potential Utility of Eye Movements in the Detection and Characterization of Everyday Functional Difficulties in Mild Cognitive Impairment

Seligman

Giovannetti

2015

Neuropsychol Rev

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“…The modest findings of our present meta-analysis may be because of a lack of statistical power from having multiple, small, single-site samples. Clinical heterogeneity might also have played a role, that is, only a subset of MCI patients develop AD dementia [6,25], and there may be pathologic subtypes [26]. We also demonstrated DMN hyperconnectivity in MCI and ADMCI using network-level statistics.…”

Section: Late-onset Admentioning

confidence: 62%

O3‐08‐02: Resting‐State Network Dysfunction in Alzheimer's Disease: A Systematic Review And Meta‐Analysis

Badhwar

Tam

Dansereau

et al. 2016

Alzheimer's & Dementia

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Introduction: We performed a systematic review and meta-analysis of the Alzheimer's disease (AD) literature to examine consistency of functional connectivity alterations in AD dementia and mild cognitive impairment, using resting-state functional magnetic resonance imaging. Methods: Studies were screened using a standardized procedure. Multiresolution statistics were performed to assess the spatial consistency of findings across studies. Results: Thirty-four studies were included (1363 participants, average 40 per study). Consistent alterations in connectivity were found in the default mode, salience, and limbic networks in patients with AD dementia, mild cognitive impairment, or in both groups. We also identified a strong tendency in the literature toward specific examination of the default mode network. Discussion: Convergent evidence across the literature supports the use of resting-state connectivity as a biomarker of AD. The locations of consistent alterations suggest that highly connected hub regions in the brain might be an early target of AD.

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“…Another study identified four cognitive subtypes in a small sample of patients with AD dementia and/or vascular dementia 15. Statistical clustering methods have also been used to identify cognitive subtypes in patients with mild cognitive impairment 13 14. One recently published study performed principle component analysis based on neuropsychological test results of a small sample of patients with AD dementia, followed by LCA 16.…”

Section: Discussionmentioning

confidence: 99%

The identification of cognitive subtypes in Alzheimer's disease dementia using latent class analysis

Scheltens

Galindo-Garré

Pijnenburg

et al. 2015

J Neurol Neurosurg Psychiatry

100

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Progression to dementia in memory clinic patients without dementia

Cited by 22 publications

References 35 publications

The Potential Utility of Eye Movements in the Detection and Characterization of Everyday Functional Difficulties in Mild Cognitive Impairment

The Potential Utility of Eye Movements in the Detection and Characterization of Everyday Functional Difficulties in Mild Cognitive Impairment

O3‐08‐02: Resting‐State Network Dysfunction in Alzheimer's Disease: A Systematic Review And Meta‐Analysis

The identification of cognitive subtypes in Alzheimer's disease dementia using latent class analysis

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