Progression risk stratification with six-minute walk gait speed trajectory in multiple sclerosis
Myla D. Goldman,
Shanshan Chen,
Robert Motl
et al.
Abstract:BackgroundMultiple Sclerosis (MS) disease progression has notable heterogeneity among patients and over time. There is no available single method to predict the risk of progression, which represents a significant and unmet need in MS.MethodsMS and healthy control (HC) participants were recruited for a 2-year observational study. A latent-variable growth mixture model (GMM) was applied to cluster baseline 6-min walk gait speed trajectories (6MWGST). MS patients within different 6 MWGST clusters were identified … Show more
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