Progression of Visual Field Defects in Leber Hereditary Optic Neuropathy: Experience of the LHON Treatment Trial

Newman, Nancy J.; Biousse, Valérie; Newman, Steven A.; Bhatti, M. Tariq; Hamilton, Steven R.; Farris, Bradley K.; Lesser, Robert L.; Turbin, Roger E.

doi:10.1016/j.ajo.2005.12.045

Cited by 43 publications

(27 citation statements)

References 20 publications

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“…One work found a mild reduction in the foveal sensitivity in glaucoma in 15/35 patients evaluated but no values were present by the authors [51]. We found one study reporting quantitative reduction values for foveal light detection sensitivity in subjects with Leber's Hereditary Optical Neurophaty (LHON) [52]. Those authors reported a reduction in the foveal sensitivity ranging from 2.7 to 10.3dB compared to the baseline.…”

Section: Discussionmentioning

confidence: 87%

Aging Effects in Psychophysical Foveal Light Detection Thresholds

Pulchinelli¹

2013

PBS

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Foveal light detection sensitivity was evaluated in 348 volunteers covering a large age range using an automated perimetry performed in the Humphrey Field Analyzer II. Foveal sensitivity was measured using the Humphrey's 4-2 bracketing strategy with a 30 dB initial stimulus intensity, at an inferior visual field location, a 0.431 (4mm 2 , viewed at 30 cm; Goldmann III) spot of white light is presented on a 10 cd/m2 white background. The sensitivity measurement was performed monocularly in both eyes randomly chosen. Our results showed a negative moderate correlation between age and the light sensitivity detection of OD (r= -0.5591; p< 0.001) and OS (r= -0.6021, p< 0.001). A moderate positive correlation was obtained between the light sensitivity of the two eyes (r= -0.5986; p< 0.001). We conclude reporting aging effect in the foveal sensitivity light detection suggesting functional decrease in perceptual function guide by developmental changes. Tolerance limits for normative purposes were measured.

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Section: Discussionmentioning

confidence: 87%

Aging Effects in Psychophysical Foveal Light Detection Thresholds

Pulchinelli¹

2013

PBS

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“…The central scotoma of ON can be differentiated from the centrocecal scotoma seen in patients with AION as the latter is not centered at the fixation point and has a characteristic steep border [97]. LHON is characterized by the presence of cecocentral defect that progresses to central defect, suggesting involvement of the papillomacular bundle [98]. The defect in LHON may follow similar pattern between the two eyes [98].…”

Section: Visual Field Examinationmentioning

confidence: 97%

“…LHON is characterized by the presence of cecocentral defect that progresses to central defect, suggesting involvement of the papillomacular bundle [98]. The defect in LHON may follow similar pattern between the two eyes [98]. In glaucoma, the VF defects are generally present between 5 and 30 from the fixation point and involve the arcuate nerve fibers [99].…”

Section: Visual Field Examinationmentioning

confidence: 99%

Clinical update in optic nerve disorders

Agarwal¹,

Hanumunthadu

Afrasiabi³

et al. 2015

Expert Review of Ophthalmology

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“…With disease progression, the VF defects gradually extend from the temporal to the nasal side, in the opposite direction to that of VF recovery after therapy. A previous study [18] suggested that VF defects are most likely to occur in the central-temporal region, and that the VF recovered last, had the most difficulty with recovery, and was the most likely to be permanently damaged. In the pathogenesis of LHON, damage initially occurs in the maculopapular bundle and then gradually extends to the peripheral retina.…”

Section: Discussionmentioning

confidence: 99%

Visual Field Variability after Gene Therapy for Leber’s Hereditary Optic Neuropathy

et al. 2018

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Purpose: To assess changes in visual field (VF) values after gene therapy for Leber’s hereditary optic neuropathy (LHON). Methods: VF recovery, VF indices, and mean deviation in injected and uninjected eyes, before and after gene therapy, were examined in 2 groups of patients according to disease duration (≤2 years and > 2 years). Nine patients with LHON were treated by monocular intravitreal injection of AAV2-ND4. Finally, 7 patients were considered for subsequent comparisons; the first and second eyes were treated separately. Results: There were no significant differences in VF indices and mean deviation between injected and uninjected eyes (p = 0.910 and p = 0.929, respectively). However, there was a significant difference before and after injection (p = 0.016 and p = 0.015, respectively). There was no significant difference in VF improvement between patients with ≤2 years’ disease duration and those with a longer disease duration. Conclusion: There was a statistically significant VF improvement after gene therapy. This suggests that monocular intravitreal injection of AAV2-ND4 can improve binocular VF values. This study also suggests that gene therapy can be effective in patients with a disease duration of > 2 years.

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Progression of Visual Field Defects in Leber Hereditary Optic Neuropathy: Experience of the LHON Treatment Trial

Cited by 43 publications

References 20 publications

Aging Effects in Psychophysical Foveal Light Detection Thresholds

Aging Effects in Psychophysical Foveal Light Detection Thresholds

Clinical update in optic nerve disorders

Visual Field Variability after Gene Therapy for Leber’s Hereditary Optic Neuropathy

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