Progression of Segment-Specific Carotid Artery Intima-Media Thickness in Young Adults (from the Bogalusa Heart Study)

Nguyen, Quoc Manh; Toprak, Ahmet; Xu, Jihua; Srinivasan, Sathanur R.; Chen, Wei; Berenson, Gerald S.

doi:10.1016/j.amjcard.2010.08.054

Cited by 19 publications

(20 citation statements)

References 25 publications

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“…[13,21] Nguyen et al have reported the association between progression of segment-specific carotid IMT and traditional risk factors such as age, race, glucose, cholesterol, and BP level. [22] However, the influence of BPV on different carotid artery locations has been scantly studied. Thus, our present study explored the associations between BPV and segment-specific measurements of carotid IMT.…”

Section: Discussionmentioning

confidence: 99%

Influence of blood pressure variability on early carotid atherosclerosis in hypertension with and without diabetes

Chen

et al. 2016

Medicine

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Carotid intima-media thickness (IMT) has been one widely used index of early carotid atherosclerosis. We speculated that the influence of blood pressure variability (BPV) on early carotid atherosclerosis may be varied by the location of the carotid artery and diabetes history. Thus, the goal of this study was to evaluate the effects of BPV on early arteriosclerosis progression in different segments of the carotid artery for hypertension with and without diabetes.A total of 148 hypertension patients who underwent 24 hours ambulatory blood pressure (BP) monitoring and carotid ultrasonography were enrolled in this study. Of them, 84 subjects were without diabetes, and 64 subjects were with diabetes. Short-term BPV during daytime, nighttime, and over 24 hours were evaluated through standard deviation (SD) and average real variability (ARV). We measured carotid IMT at left and right common carotid artery (CCA), carotid bulb, and the origin of the internal carotid artery (ICA). The associations between segment-specific measurements of carotid IMT and 24 hours ambulatory BPV were analyzed.We found that IMT at the common carotid artery (CCA-IMT) and IMT at the internal carotid artery (ICA-IMT) were more closely associated with BPV than was carotid bulb IMT. In addition, for all subjects, BPV was clearly associated with left CCA-IMT but not with right CCA-IMT. Furthermore, in diabetes patients, nighttime systolic BPV was independently related to mean CCA-IMT (P < 0.01) and mean bulb IMT (P < 0.01). In contrast, in nondiabetes patients, daytime and 24 hours systolic BPV was positively associated with mean CCA-IMT (P < 0.05), but not independent after adjusting for baseline characteristics such as age and sex.The findings of our study indicate a segment-specific association between carotid IMT and 24 hours ambulatory BPV, and the associations also vary according to the diabetes history. We conclude that BPV plays a distinct role in early carotid arteriosclerosis progression within different segments of the carotid artery, especially for the hypertensions with and without diabetes.

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Section: Discussionmentioning

confidence: 99%

Influence of blood pressure variability on early carotid atherosclerosis in hypertension with and without diabetes

Chen

et al. 2016

Medicine

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“…Use of statins as primary prevention has not been explored in the general paediatric population but is effective in preventing CIMT progression in children with familial hypercholesterolaemia. In the population-based Bogalusa Heart Study, hsCRP levels did not predict CIMT progression in healthy young adults over a relatively short follow-up period (2.4 years) 37. It is important to note that results from healthy cohorts and adults are difficult to extrapolate to adolescent and young adult lupus patients who have a unique cardiovascular risk profile.…”

Section: Discussionmentioning

confidence: 94%

Secondary analysis of APPLE study suggests atorvastatin may reduce atherosclerosis progression in pubertal lupus patients with higher C reactive protein

et al. 2013

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Objective Participants in the Atherosclerosis Prevention in Paediatric Lupus Erythematosus (APPLE) trial were randomised to placebo or atorvastatin for 36 months. The primary endpoint, reduced carotid intima medial thickness (CIMT) progression, was not met but atorvastatin-treated participants showed a trend of slower CIMT progression. Post-hoc analyses were performed to assess subgroup benefit from atorvastatin therapy. Methods Subgroups were prespecified and defined by age (> or ≤15.5 years), systemic lupus erythematosus (SLE) duration (> or ≤24 months), pubertal status (Tanner score ≥4 as post-pubertal or <4 as pre-pubertal), low density lipoprotein cholesterol (LDL) (≥ or <110 mg/dl) and high-sensitivity C reactive protein (hsCRP) (≥ or <1.5 mg/l). A combined subgroup (post-pubertal and hsCRP≥1.5 mg/l) was compared to all others. Longitudinal linear mixed-effects models were developed using 12 CIMT and other secondary APPLE outcomes (lipids, hsCRP, disease activity and damage, and quality of life). Three way interaction effects were assessed for models. Results Significant interaction effects with trends of less CIMT progression in atorvastatin-treated participants were observed in pubertal (3 CIMT segments), high hsCRP (2 CIMT segments), and the combined high hsCRP and pubertal group (5 CIMT segments). No significant treatment effect trends were observed across subgroups defined by age, SLE duration, LDL for CIMT or other outcome measures. Conclusions Pubertal status and higher hsCRP were linked to lower CIMT progression in atorvastatin-treated subjects, with most consistent decreases in CIMT progression in the combined pubertal and high hsCRP group. While secondary analyses must be interpreted cautiously, results suggest further research is needed to determine whether pubertal lupus patients with high CRP benefit from statin therapy. ClinicalTrials.gov identifier NCT00065806.

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“…Majority of Chinese and Hispanic participants in the MESA were not born in the US (around 96% Chinese and 70% Hispanic) and therefore less likely to be exposed to the Western culture as opposed to third or fourth generation Japanese Americans in our study (15). The Bogalusa Heart Study and the Atherosclerosis Risk in Communities study also examined racial differences in progression of CIMT between whites and blacks (13, 16, 17); these studies did not find any racial difference in progression of CIMT.…”

Section: Discussionmentioning

confidence: 99%

Significantly Greater Progression of Intima-Media Thickness of the Carotid Artery in Japanese American Men Than in White Men: The ERA JUMP Study

Ahuja

Barinas‐Mitchell

Rodríguez

et al. 2016

Canadian Journal of Cardiology

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Background Although Westernized lifestyle was associated with increased coronary heart disease (CHD) morbidity and mortality in first and second generation Japanese Americans; CHD mortality was reported to be lower in them than whites. Risk profile of CHD for third and fourth generation Japanese Americans is not known. We compared progression of CIMT between third or fourth generation Japanese Americans and whites. Methods Population-based samples of 473 men (Japanese Americans=227 and whites=246) aged 40–49 years at baseline and free of clinical cardiovascular disease were examined for CIMT at baseline (2002–06) and follow-up (2007–13). CIMT was read centrally at the University of Pittsburgh. Analysis of covariance was used to compare annualized progression of CIMT between Japanese Americans and whites, adjusting for cardiovascular risk factors and baseline CIMT. Results Progression of CIMT was significantly greater in Japanese Americans than whites both before and after adjusting for covariates (mean in μm/year [95% confidence interval]): 14.4 (12.3, 16.4) vs 9.8 (7.8, 11.7), P<0.05 and 15.1 (13.1, 17.1) vs 9.1 (7.2, 11.0), P<0.05, respectively. Age, total cholesterol/high-density lipoprotein-cholesterol, and diabetes in Japanese Americans and age, hypertension, and lipid medication in whites were significantly associated with progression of CIMT. Conclusions The significantly greater progression of CIMT in Japanese Americans than whites might suggest a higher burden of CHD in Japanese Americans than whites in the future. The current study identifies Japanese Americans as an important target group for prevention of CHD. Future research assessing carotid plaque in addition to CIMT is warranted.

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Progression of Segment-Specific Carotid Artery Intima-Media Thickness in Young Adults (from the Bogalusa Heart Study)

Cited by 19 publications

References 25 publications

Influence of blood pressure variability on early carotid atherosclerosis in hypertension with and without diabetes

Influence of blood pressure variability on early carotid atherosclerosis in hypertension with and without diabetes

Secondary analysis of APPLE study suggests atorvastatin may reduce atherosclerosis progression in pubertal lupus patients with higher C reactive protein

Significantly Greater Progression of Intima-Media Thickness of the Carotid Artery in Japanese American Men Than in White Men: The ERA JUMP Study

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