1997
DOI: 10.1038/ki.1997.475
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Progression of renal damage in human glomerulonephritides: Is there sleight of hand in winning the game?

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Cited by 81 publications
(60 citation statements)
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References 183 publications
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“…In the normal kidney, macrophages are mostly restricted to the renal capsule, pelvic wall, and adventitia of large vessels (34). However, in both inflammatory and noninflammatory renal disease, macrophage infiltration is a prominent feature (10,(35)(36)(37), where their cellular contents of reactive oxygen intermediates, proteases, inflammatory cytokines, and growth factors including TGF-␤ itself (10,35,38) are viewed as playing a significant role in mediating renal injury (35). Thus, the ability of tranilast to reduce macrophage accumulation, as noted in the present study, may potentially contribute to the observed attenuation of renal injury.…”
Section: Discussionmentioning
confidence: 99%
“…In the normal kidney, macrophages are mostly restricted to the renal capsule, pelvic wall, and adventitia of large vessels (34). However, in both inflammatory and noninflammatory renal disease, macrophage infiltration is a prominent feature (10,(35)(36)(37), where their cellular contents of reactive oxygen intermediates, proteases, inflammatory cytokines, and growth factors including TGF-␤ itself (10,35,38) are viewed as playing a significant role in mediating renal injury (35). Thus, the ability of tranilast to reduce macrophage accumulation, as noted in the present study, may potentially contribute to the observed attenuation of renal injury.…”
Section: Discussionmentioning
confidence: 99%
“…The interactions between inflammatory infiltrates and resident tubular cells contribute to ongoing inflammation, formation and activation of myofibroblasts, and ultimately interstitial fibrosis. The pivotal role of inflammatory infiltration in the progression of tubulointerstitial fibrosis is supported by the strict correlation between tubular atrophy, interstitial fibrosis, and the extent of interstitial infiltration (1,2).…”
mentioning
confidence: 99%
“…A further reason for its importance is that ϳ25-50% of patients progress to end-stage kidney disease over 10 years (33). Thus MGN has a different and more progressive clinical course compared with the nonprogressive benign character of minimal-change nephrotic syndrome (33). HgCl 2 has been known to induce a systemic autoimmune disease, including membranous nephropathy with IgG deposits.…”
mentioning
confidence: 99%