Progression of putaminal degeneration in multiple system atrophy: A serial diffusion MR study

Seppi, Klaus; Schocke, Michael; Mair, Katherina J.; Esterhammer, Regina; Scherfler, Christoph; Geser, Felix; Kremser, Christian; Boesch, Sylvia; Jaschke, Werner; Poewe, Werner; Wenning, Gregor K.

doi:10.1016/j.neuroimage.2005.12.006

Cited by 94 publications

(89 citation statements)

References 35 publications

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“…These were found in the vicinity of the putamen, complying with previous reports [8,23,25]. It is tempting to speculate that these changes represent an early stage of neuronal degeneration and are due to the same pathology as the well-known T2 hyperintensive rim around the putamen frequently found in structural MRI in later stages of MSAp (see also Limitations).…”

Section: Discussionsupporting

confidence: 90%

Diffusion Tensor Imaging in Idiopathic Parkinson's Disease and Multisystem Atrophy (Parkinsonian Type)

Cnyrim¹,

Kupsch

Ebersbach

et al. 2013

Neurodegener Dis

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Background: Differentiation between Parkinson's disease (PD) and atypical Parkinson syndromes (AP) is usually based on clinical examination, but can be challenging especially at early stages of the diseases. Diffusion tensor imaging (DTI) allows for differentiation between PD and AP with good specificity. It is a promising tool for clinical application, but has not been elaborated completely with respect to methodology and validity. Objective: In this study we evaluated differences of the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) within white brain matter between patients with PD and multisystem atrophy of the parkinsonian type (MSAp). Materials and Methods: DTI data of 9 PD and 9 MSAp patients were compared by means of a hypothesis-free whole-brain analysis algorithm (TBSS) focusing on changes within white matter. Results: We found significantly higher values of the ADC in the MSAp group in the anterior limb of the inner capsule, superior parts of the corona radiata, and lateral periputaminal white matter. Group differences in FA values were not significant. Conclusion: Changes of the ADC close to the putamen proved most consistent and seem to be promising for the ongoing clinical implementation of DTI for the differentiation of hypokinetic-rigid movement disorders.

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Section: Discussionsupporting

confidence: 90%

Diffusion Tensor Imaging in Idiopathic Parkinson's Disease and Multisystem Atrophy (Parkinsonian Type)

Cnyrim¹,

Kupsch

Ebersbach

et al. 2013

Neurodegener Dis

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“…Iron imaging by quantitative T2 measurement has shown increased regional iron content in the SNc (17)(18)(19)(20). Several authors reported increased putaminal apparent diffusion coefficient in patients with MSA (21,22) and PSP (23) and increased diffusivity in patients with MSA (24).…”

Section: Discussionmentioning

confidence: 99%

Reduction of Neuromelanin-Positive Nigral Volume in Patients with MSA, PSP and CBD

2011

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Objective Diseases presenting extrapyramidal symptoms are accompanied by nigral cell loss. In the previous study, we demonstrated the reduction of the neuromelanin-positive volume of substantia nigra (SN) pars compacta (SNc) in patients with Parkinson's disease (PD) using 3-Tesla MRI. In the present study we investigated the neuromelanin-positive SNc volume in patients with the other parkinsonian disorders including multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) and compared the results with those with PD, spinocerebellar ataxia (SCA) and controls. Patients and Methods Axial T1-weighted (T1W) images were obtained with a 3-Tesla MRI scanner. The border of the neuromelanin-positive region of the SNc was traced manually on these images with a pentablet pointing device and the SNc volume was calculated. The SNc volumes of 28 patients with MSA, 11 patients with PSP and 10 patients with CBD were compared with those of 80 patients with PD, 9 patients with SCA and 54 patients who had suffered mild acute ischemic stroke as controls. The mean volumes for the left and right SN were used for statistical analyses. Results The volumes of the neuromelanin-positive SNc region in patients with MSA, PSP and CBD, but not SCA were reduced to the same extent as PD patients compared with controls. Conclusion Reduced volume of the neuromelanin-positive SNc region of patients with MSA, PSP and CBD was detected by neuromelanin MR imaging. Volumetric evaluation of neuromelanin MR imaging may provide a biomarker of nigral degeneration in patients with MSA, PSP and CBD as in patients with PD.

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“…In line with the known underlying neuropathology in MSA-P, a more severe involvement of posterior compared with anterior putaminal diffusivity was found in patients with MSA-P [125,129] . Interestingly, several studies have found a correlation of putaminal diffusivity measures with disease severity [58,108,129,130] , which is of particular relevance to the use of MRI measures as biomarkers for disease progression.…”

Section: Diffusion-weighted and Diffusion Tensor Imagingmentioning

confidence: 96%

Significance of MRI in Diagnosis and Differential Diagnosis of Parkinson’s Disease

et al. 2010

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The differential diagnosis of parkinsonian syndromes is considered one of the most challenging in neurology, even for movement disorder specialists. Despite published consensus operational criteria for the diagnosis of Parkinson’s disease (PD) and the various atypical parkinsonian disorders (APDs) such as progressive supranuclear palsy, multiple system atrophy, and corticobasal syndrome, the clinical separation of APDs from PD carries a high rate of misdiagnosis. However, an early differentiation between APD and PD, each characterized by a largely different natural history, is crucial for determining the prognosis and choosing a treatment strategy. Despite limitations, the different modern magnetic resonance (MR) techniques have undoubtedly added to the differential diagnosis of neurodegenerative parkinsonism. Conventional MRI with visual assessment of T₂- and T₁-weighted imaging as well as various advanced MRI techniques offer objective measures and may therefore be useful tools in the diagnostic workup of PD and APDs. In clinical practice, conventional MRI is a well-established method for the exclusion of symptomatic parkinsonism due to other pathologies such as tumors, cerebral ischemia or inflammatory diseases. Furthermore, over the past two decades, advances in MR techniques have enabled to quantitatively illustrate abnormalities in the basal ganglia and infratentorial structures in APDs by methods such as magnetic resonance volumetry, diffusion-weighted imaging, magnetization transfer imaging and proton magnetic resonance spectroscopy. This article aims to review research findings on the value of MRI techniques in the differential diagnosis of neurodegenerative parkinsonian disorders.

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Progression of putaminal degeneration in multiple system atrophy: A serial diffusion MR study

Cited by 94 publications

References 35 publications

Diffusion Tensor Imaging in Idiopathic Parkinson's Disease and Multisystem Atrophy (Parkinsonian Type)

Diffusion Tensor Imaging in Idiopathic Parkinson's Disease and Multisystem Atrophy (Parkinsonian Type)

Reduction of Neuromelanin-Positive Nigral Volume in Patients with MSA, PSP and CBD

Significance of MRI in Diagnosis and Differential Diagnosis of Parkinson’s Disease

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