Progression of paroxysmal to persistent atrial fibrillation: 10-year follow-up in the Canadian Registry of Atrial Fibrillation

Atrial fibrillation and stroke: a practical guide

“…These results might be more applicable to contemporary practice, given advances in the management of other cardiovascular risk factors. However, in practice, a quarter of patients with paroxysmal AF progress to persistent or permanent AF within 5 years, and a third within 10 years 13. In our view, it is therefore reasonable to treat paroxysmal, persistent and permanent AF in the same way.…”

Long‐term outcomes of catheter ablation in patients with longstanding persistent atrial fibrillation lasting less than 2 years

“…There is a significant body of evidence describing the natural history of paroxysmal and persistent AF and the atrial structural changes linked to arrhythmia perpetuation . As an example, the recent Canadian Registry of Atrial Fibrillation (CARAF) reported a 10‐year rate of progression to persistent AF of about 36% among patients presenting with paroxysmal AF …”

“…[16][17][18] As an example, the recent Canadian Registry of Atrial Fibrillation (CARAF) reported a 10-year rate of progression to persistent AF of about 36% among patients presenting with paroxysmal AF. 16 However, data on progression of structural substrate changes and CA success rate in LSPAF patients on the basis of AF duration are still scarce. Specifically, outcomes of different ablation strategies among patients in the initial stages of their LSPAF status, such as those with continuous AF lasting less than 2 years, have not been previously reported elsewhere.…”

Review on Atrial Fibrillation

“…3 Padfield et al, in a manuscript published in June of this year, sought to determine the rate of progression from paroxysmal to persistent AF over a 10-year period. 4 Analyzing data from the Canadian Registry of Atrial Fibrillation, they demonstrated that more than 50% of patients with paroxysmal AF over 10 years will either have progressed to having persistent AF, or have died. The rate of progression was 36.3% at 10 years.…”