Progression of Osteoporosis After Kidney Transplantation in Patients With End-Stage Renal Disease

Park, W.Y.; Han, Seungyeup; Choi, Bum Soon; Park, C.W.; Yang, Chul Woo; Kim, Y.-S.; Kim, J.I.; Moon, In Sung; Chung, Byung Ha

doi:10.1016/j.transproceed.2017.03.038

Cited by 15 publications

(22 citation statements)

References 14 publications

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“…In the regression analysis, these findings lost their significance. The risk of first-year abnormal BMD scores was increased 6.81 times by heterozygous Cdx2 polymorphism, 23.32 times by homozygous Cdx2 polymorphism, 4.01 times by heterozygous ApaI polymorphism, and 6.30 times by homozygous ApaI polymorphism. Several studies investigated the VDR polymorphisms with hyperparathyroidism secondary to CKD.…”

Section: Discussionmentioning

confidence: 92%

“…However, the osteoporosis mechanism after kidney transplantation is much more complicated. CKDmineral and bone disorder (MBD) residues and persistent hyperparathyroidism considerably affect bone health [3,4]. Other suggested risk factors for osteoporosis after kidney transplantation are calcium and vitamin D deficiencies, age, female gender, and specific vitamin D receptor (VDR) polymorphisms (BsmI) [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D receptor polymorphisms and bone health after kidney transplantation

Korucu¹,

Tükün²,

Helvacı³

et al. 2021

Turk J Med Sci

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Background/aim: Bone disease is one of the most prominent complications after kidney transplantation. Bone diseases include osteoporosis, persistent secondary hyperparathyroidism, and avascular necrosis (AVN). We investigated the relationship between the polymorphisms of the vitamin D receptor (VDR) gene and bone diseases occurring after kidney transplantation. Materials and methods: The study consists of 234 kidney allograft recipients with a minimum follow-up of five years after kidney transplantation. Patients with glomerular filtration rates less than 30 ml/min/1.73m 2 , a history of parathyroidectomy, bisphosphonate use pre-or posttransplantation, and cinacalcet use post-transplantation excluded. We evaluated associations between the polymorphisms of the VDR gene (BsmI, TaqI, ApaI, FokI, and Cdx2), the first-year bone mineral density (BMD) scores, persistent secondary hyperparathyroidism, and AVN. Results: Patients with low BMD scores were significantly younger (p=0.03) and had higher intact parathormone (iPTH) levels (p=0.03). Cdx2 TT genotype significantly increases the risk of low BMD scores (OR:3.34, p=0.04). Higher phosphate levels were protective against abnormal BMD scores (OR:0.53; p=0.03). Patients with persistent hyperparathyroidism had significantly longer dialysis vintage and higher pretransplantation iPTH levels (p=0.02 and p<0.001, respectively). Cdx2, CT/TT, and ApaI CA/AA genotypes significantly increase the risk of persistent

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Vitamin D receptor polymorphisms and bone health after kidney transplantation

Korucu¹,

Tükün²,

Helvacı³

et al. 2021

Turk J Med Sci

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“…Maintaining the balance between bone formation (osteoblasts) and bone resorption (osteoclasts) is the main factor leading to bone metabolism. Once bone resorption exceeds the stratum, the risk of osteoporosis and fracture in bone increases [10]. In the current study, the activity of TRAP in scales was detected to evaluate the activity of osteoclasts.…”

Section: Discussionmentioning

confidence: 97%

Preventive Effects of Evodiamine on Dexamethasone-Induced Osteoporosis in Zebrafish

Yin

Wang

et al. 2019

BioMed Research International

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The aim of this study was to investigate the effect of evodiamine (EV) on dexamethasone-induced osteoporosis in zebrafish. Zebrafish larvae were exposed to different concentrations of dexamethasone to obtain the osteoporosis in zebrafish. Calcium, phosphorus, and alizarin red staining determination were performed to evaluate the effects of EV on bone mineralization. Alkaline phosphatase (ALP), hydroxyproline (HP), and tartrate resistant acid phosphatase (TRAP) were also measured by commercial kits. The expression of MMP3-OPN-MAPK pathway in zebrafish was measured by Western blot. RT-PCR was used to determine mRNA levels of MMP3, OPN, and MAPK. EV could significantly increase the content of calcium and phosphorus. The results of alizarin red staining showed that EV could significantly increase the calcium sink of horse fish, increasing the area of bone formation. EV could increase the content of hydroxyproline in zebrafish. EV also increased ALP and TRAP in zebrafish. Western blot and RT-PCR results showed that EV restored the MMP3-OPN-MAPK pathway in zebrafish. In conclusion, we found that EV can alleviate dexamethasone-induced osteoporosis in zebrafish. The mechanism is related to activating MMP3-OPN-MAPK pathway and then activating bone remodeling.

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“…Kidney transplant recipients are prone to metabolic bone diseases and have a high risk of fractures. A high prevalence of osteoporosis (ranged 13.9% to 53% [1][2][3][4][5]) and osteopenia (ranged 7 % to 52.5% [3,[5][6][7][8][9]), leading to fractures, has been reported after kidney transplantation (KT). Although hip fractures often present with clinical signs, most vertebral fractures occur atypically [10].…”

Section: Introductionmentioning

confidence: 99%

Clinical predictors of incipient vertebral fractures and bone mineral density in kidney transplant patients

Yavuz

Aydín

Apaydın

et al. 2021

Preprint

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Purpose: Kidney transplant recipients are prone to metabolic bone diseases and consequent fractures. This study aimed to evaluate the incidence of incipient vertebral fractures, osteopenia, osteoporosis, and the clinical factors associated with incipient vertebral fractures in a group of kidney transplant patients. Methods: Two hundred sixty-four patients (F/M:124/140, 45.3±13 years) who had undergone kidney transplantation between 2008 and 2018 and who were followed up at least one year in third care centers were included in this multicenter retrospective study. Bone mineral densitometry was performed using dual-energy X-ray absorptiometry. Vertebral fractures were assessed semi-quantitatively using conventional thoracolumbar lateral radiography in 202 of the patients. Results: Vertebral fractures were observed in 56.4% (n=114) of the study group. Severe vertebral fractures were observed in 30.7% (n=62) of the patients in vertebral X-ray evaluation. The frequency of osteoporosis was 20.0% (53 of 264 patients), and osteopenia was 35.6% (94 of 264 patients). BMD levels were in the normal range in 40.3% (n=46) of the subjects with vertebral fractures. It was in the osteoporotic range in 20.1% (n=23) and the osteopenic range in 40.3% (n=46). Serum calcium, parathormone vitamin, and creatinine levels were similar between the patients with and without vertebral fractures. Femoral neck BMD was negatively correlated with age (r: −0.21, p<0.001) and positively correlated with body mass index (r:0.29, p<0.001). Vertebral fractures were associated with age, duration of hemodialysis, BMI, femoral neck Z score (R2: 37.8%, p=0.027). Conclusion: BMD was in the normal or osteopenic range in 79.8% in our cohort of renal transplant patients with incipient vertebral fractures. As incipient vertebral fractures can be observed in patients with normal BMD levels in kidney transplant recipients, conventional X-ray screening for vertebral fractures may be beneficial for a proper therapy decision of metabolic bone disease in kidney transplant recipients.

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Progression of Osteoporosis After Kidney Transplantation in Patients With End-Stage Renal Disease

Cited by 15 publications

References 14 publications

Vitamin D receptor polymorphisms and bone health after kidney transplantation

Vitamin D receptor polymorphisms and bone health after kidney transplantation

Preventive Effects of Evodiamine on Dexamethasone-Induced Osteoporosis in Zebrafish

Clinical predictors of incipient vertebral fractures and bone mineral density in kidney transplant patients

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