Progression of neuropsychiatric symptoms in young-onset versus late-onset Alzheimer’s disease

Gumus, Melisa; Multani, Namita; Mack, Michael L.; Tartaglia, Carmela; Initiative, Alzheimer’s Disease Neuroimaging

doi:10.1007/s11357-020-00304-y

Cited by 25 publications

(29 citation statements)

References 43 publications

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“…The cause for increased BPSD in EOAD is likely multifactorial and includes both social and biological factors. Receiving a diagnosis of AD is probably more emotionally difficult for EOAD than LOAD patients due to their younger age, more responsibilities within their families such as taking care of children and holding down a job [ 29 ]. In addition, the pathophysiology of AD spreads in a more rapid and aggressive manner in EOAD compared to LOAD [ 51 ] determining a worse prognosis [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

“…The above reported contrasting results were probably due to methodological differences and small sample sizes particularly for EOAD patients [23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 94%

“…The only two longitudinal studies [28,29] showed totally different figures of BPSD in EOAD compared to LOAD over two years and four years of assessment, respectively.…”

Section: Introductionmentioning

confidence: 94%

“…Although most AD patients display several BPSD [7,21] their occurrence, prevalence, and severity changes depend on the type of sample and setting considered [22]. A growing body of evidence indicates that there are differences in the manifestation of BPSD between early-onset (EOAD, onset <65 years old) and late-onset (LOAD, onset >65 years) AD patients [23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

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A Comparison of Behavioral and Psychological Symptoms of Dementia (BPSD) and BPSD Sub-Syndromes in Early-Onset and Late-Onset Alzheimer’s Disease

Altomari

Bruno

Laganà

et al. 2022

JAD

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Background: Behavioral and psychological symptoms of dementia (BPSD) have a large impact on the quality of life of patients with Alzheimer’s disease (AD). Few studies have compared BPSD between early-onset (EOAD) and late-onset (LOAD) patients, finding conflicting results. Objective: The aims of this study were to: 1) characterize the presence, overall prevalence, and time of occurrence of BPSD in EOAD versus LOAD; 2) estimate the prevalence over time and severity of each BPSD in EOAD versus LOAD in three stages: pre-T0 (before the onset of the disease), T0 (from onset to 5 years), and T1 (from 5 years onwards); 3) track the manifestation of BPSD sub-syndromes (i.e., hyperactivity, psychosis, affective, and apathy) in EOAD versus LOAD at T0 and T1. Methods: The sample includes 1,538 LOAD and 387 EOAD diagnosed from 1996 to 2018. Comprehensive assessment batteries, including the Neuropsychiatric Inventory (NPI), were administered at the first medical assessment and at different follow-up period. Results: The overall prevalence for the most of BPSD was significantly higher in EOAD compared to LOAD whereas most BPSD appeared significantly later in EOAD patients. Between the two groups, from pre-T0 to T1 we recorded a different pattern of BPSD prevalence over time as well as for BPSD sub-syndromes at T0 and T1. Results on severity of BPSD did not show significant differences. Conclusion: EOAD and LOAD represent two different forms of a single entity not only from a neuropathological, cognitive, and functional level but also from a psychiatric point of view.

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Section: Discussionmentioning

confidence: 99%

“…The above reported contrasting results were probably due to methodological differences and small sample sizes particularly for EOAD patients [23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 94%

“…The only two longitudinal studies [28,29] showed totally different figures of BPSD in EOAD compared to LOAD over two years and four years of assessment, respectively.…”

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Comparison of Behavioral and Psychological Symptoms of Dementia (BPSD) and BPSD Sub-Syndromes in Early-Onset and Late-Onset Alzheimer’s Disease

Altomari

Bruno

Laganà

et al. 2022

JAD

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“…This thought is well-aligned with the notion that the healthy older people in this study still showed a significant decline in cognitive function as compared with younger people. Thus, the loss of cognitive function is often considered a natural path to healthy aging, but some go on to develop accelerated cognitive impairment and even Alzheimer’s Disease between 60 to 70 years of age [ 40 ]. An early detection program involving measurable physical characteristics, such as extracellular water, offers the opportunity to assess the extent to which cognitive status changes with lifestyle interventions that lower the extracellular to intracellular water balance ratio.…”

Section: Discussionmentioning

confidence: 99%

Extracellular to Intracellular Body Water and Cognitive Function among Healthy Older and Younger Adults

Lee

Shields

2022

JFMK

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Compromised cognitive function is associated with increased mortality and increased healthcare costs. Physical characteristics including height, weight, body mass index, sex, and fat mass are often associated with cognitive function. Extracellular to intracellular body water ratio offers an additional anthropometric measurement that has received recent attention because of its association with systemic inflammation, hypertension, and blood–brain barrier permeability. The purposes of this study were to determine whether extracellular to intracellular body water ratios are different between younger and older people and whether they are associated with cognitive function, including executive function and attention, working memory, and information processing speed. A total of 118 healthy people (39 older; 79 younger) participated in this study. We discovered that extracellular to intracellular body water ratio increased with age, was predictive of an older person’s ability to inhibit information and stay attentive to a desired task (Flanker test; R2 = 0.24; p < 0.001), and had strong sensitivity (83%) and specificity (91%) to detect a lower executive function score. These findings support that extracellular to intracellular body water ratio offers predictive capabilities of cognitive function, even in a healthy group of elderly people.

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Baseline neuropsychiatric symptoms and psychotropic medication use midway through data collection of the Longitudinal Early‐Onset Alzheimer's Disease Study (LEADS) cohort

Polsinelli,

Wonderlin,

Hammers

et al. 2023

Alzheimer's & Dementia

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IntroductionWe examined neuropsychiatric symptoms (NPS) and psychotropic medication use in a large sample of individuals with early‐onset Alzheimer's disease (EOAD; onset 40‐64 years) at the midway point of data collection for the Longitudinal Early‐onset Alzheimer's Disease Study (LEADS).MethodsBaseline NPS (Neuropsychiatric Inventory – Questionnaire; Geriatric Depression Scale) and psychotropic medication use from 282 participants enrolled in LEADS were compared across diagnostic groups – amyloid‐positive EOAD (n = 212) and amyloid negative early‐onset non‐Alzheimer's disease (EOnonAD; n = 70).ResultsAffective behaviors were the most common NPS in EOAD at similar frequencies to EOnonAD. Tension and impulse control behaviors were more common in EOnonAD. A minority of participants were using psychotropic medications, and use was higher in EOnonAD.DiscussionOverall NPS burden and psychotropic medication use were higher in EOnonAD than EOAD participants. Future research will investigate moderators and etiological drivers of NPS, and NPS differences in EOAD versus late‐onset AD.

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Progression of neuropsychiatric symptoms in young-onset versus late-onset Alzheimer’s disease

Cited by 25 publications

References 43 publications

A Comparison of Behavioral and Psychological Symptoms of Dementia (BPSD) and BPSD Sub-Syndromes in Early-Onset and Late-Onset Alzheimer’s Disease

A Comparison of Behavioral and Psychological Symptoms of Dementia (BPSD) and BPSD Sub-Syndromes in Early-Onset and Late-Onset Alzheimer’s Disease

Extracellular to Intracellular Body Water and Cognitive Function among Healthy Older and Younger Adults

Baseline neuropsychiatric symptoms and psychotropic medication use midway through data collection of the Longitudinal Early‐Onset Alzheimer's Disease Study (LEADS) cohort

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