Progression of Hearing Loss in the Aging Population: Repeated Auditory Measurements in the Rotterdam Study

Rigters, Stephanie C.; Schroeff, Marc P. van der; Papageorgiou, Grigorios; Jong, Robert J. Baatenburg de; Goedegebure, André

doi:10.1159/000492203

Cited by 45 publications

(56 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous epidemiologic studies have examined hearing loss progression but group all ≥ 80 or ≥ 85 year olds into a single category. 1,[17][18][19] Although certain studies have characterized the older-old, they have used convenience sampling in audiology practices, where hearing loss will be biased because those who seek audiologic care tend to have worse hearing. 20,21 There is no study that accurately characterizes the progression of hearing loss in participants aged 80 years and older in the United States.…”

Section: Introductionmentioning

confidence: 99%

Modeling Hearing Loss Progression and Asymmetry in the Older Old: A National Population‐Based Study

2020

View full text Add to dashboard Cite

The progression and asymmetry of age-related hearing loss has not been well characterized in those 80 years of age and older because public datasets mask upper extremes of age to protect anonymity. We aim to characterize the progression, severity, and asymmetry of hearing loss in those 80 years of age and older using a representative, national database. Methods: Cross-sectional, multicentered U.S. epidemiologic analysis using the National Health and Nutrition Examination Survey (NHANES) 2005 to 2006, 2009 to 2010, and 2011 to 2012 cycles. Subjects included noninstitutionalized, civilian adults aged 80 years and older (n = 621). Federal security clearance was granted to access publicly restricted age data. Outcome measures included pure-tone average (PTA) air conduction thresholds and the 4-frequency PTA. Results: Six hundred and twenty-one subjects were 80 years old or older (mean = 84.2 years, range = 80-104 years), representing 10,600,197 Americans. The average PTA was 38.9 dB (95% confidence interval [CI] = 37.8, 40.0). Hearing loss exhibited constant acceleration across the adult lifespan at a rate of 0.0052 dB/year 2 (95% CI = 0.0049, 0.0055). This model predicted mean PTA within 2 dB of accuracy for most ages between 20 and 100 years. From age 80 years to approximately 100 years, the average PTA difference between the better and worse ear was 6.75 dB (95% CI = 5.8, 7.1). This asymmetry was relatively constant (i.e., nonsignificant linear regression coefficient of asymmetry over age = 0.07 [95% CI = −0.01, 0.2]). Conclusion: Hearing loss steadily and predictably accelerates across the adult lifespan to at least age 100 years, becoming near universal. These population-level statistics will guide treatment and policy recommendations for hearing health in the older old.

show abstract

Section: Introductionmentioning

confidence: 99%

Modeling Hearing Loss Progression and Asymmetry in the Older Old: A National Population‐Based Study

2020

View full text Add to dashboard Cite

show abstract

“…As hearing aids can improve hearing and contribute to reestablishing the individual's participation in society, they could have a positive effect on the expected trajectory of cognition (39). However, the results of studies investigating the effect of hearing aids on cognitive function in older adults are inconclusive (40)(41)(42)(43)(44)(45)(46)(47). Recent studies have also studied the impact of unilateral cochlear implantation on the cognitive capabilities of older adults with bilateral severe-to-profound sensorineural hearing loss (28,(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61).…”

Section: Can Hearing Rehabilitation Slow Down Cognitive Decline?mentioning

confidence: 99%

Making the Case for Research on Disease-Modifying Treatments to Tackle Post-lingual Progressive Sensorineural Hearing Loss

Rompaey

2020

Front. Neurol.

View full text Add to dashboard Cite

Hearing loss not only has a significant impact on the quality of life of patients and society, but its correlation with cognitive decline in an aging population will also increase the risk of incident dementia. While current management of hearing loss is focused on hearing rehabilitation (and essentially symptomatic), patients are suffering from the burden of progressive hearing loss before hearing aids or cochlear implants are fitted. Although these devices have a significant effect on speech understanding, they do not always lead to normal speech understanding, especially in noisy environments. A significant number of patients suffer from autosomal dominantly inherited disorders that can produce progressive sensorineural hearing loss. This includes DFNA9, a disorder caused by pathologic variants in the COCH gene that leads to post-lingual profound sensorineural hearing loss and bilateral vestibulopathy. Carriers of a pathogenic variant leading to DFNA9 can be diagnosed at the pre-symptomatic or early symptomatic stage which creates a window of opportunity for treatment. Preventing hearing loss from occurring or stabilizing progression would provide the opportunity to avoid hearing aids or cochlear implants and would be able to reduce the increased incidence of dementia. While innovative therapies for restoration of hearing have been studied for restoration of hearing in case of severe-to-profound sensorineural hearing loss and congenital hearing loss, further research is needed to study how we can modify disease progression in late-onset autosomal dominant hereditary sensorineural hearing loss. Recently, gene editing strategies have been explored in autosomal dominant disorders to disrupt dominant mutations selectively without affecting wild-type alleles.

show abstract

“…Given the age heterogeneity within the group [16][17][18], we explored the relationship between hearing and hospitalization stratified by two age groups: 45-59 years vs. 60 years and above. Characteristics of participants were examined by gradient self-rated hearing status using Pearson's Chi-square test for categorical variables.…”

Section: Statistical Analysesmentioning

confidence: 99%

Hearing status gradients in the risk of hospitalization among Chinese middle-aged and older adults

Zhu

He³

2020

Preprint

View full text Add to dashboard Cite

Background: Hearing is one of the basic means of perception and communication, which is closely related with quality of life. However, hearing impairment is often unrecognized and undertreated, and impaired hearing may lead to greater burden of diseases as well as risk of hospitalization. To gain further insight into the association between hearing and hospitalization, we examined the shape and magnitude of hearing status gradients in the risk of hospitalization among Chinese middle-aged and older adults. Methods: We obtained data from a retrospective survey of the China Health and Retirement Longitudinal Study (CHARLS) conducted in 2011, 2013 and 2015, including 11,721 participants aged 45 years old and above with no hospitalization in 2011 baseline. Hospitalization variables included time to incident (first) hospitalization, annual number of hospitalizations and duration of last-time hospitalization. Cox proportional hazards models, negative binomial models and lognormal regression were fitted to examine the relationship between self-rated hearing status gradients and risk of hospitalization. Results: Of the total 11,721 participants, 54.46% reported having fair or poor hearing and 20.94% experienced at least one hospitalization during the study period. Older adults were exposed to higher risk of hospitalization than the middle-aged adults. For older adults, compared with excellent or very good hearing people, those with good, fair and poor hearing experienced a shorter time to incident (first) hospitalization, a greater annual number of hospitalizations and a longer last-time duration of hospitalization with the deterioration of hearing. However, there was no significant association for the middle-aged adults. Conclusions: We found a gradient decrease in time to first hospitalization, an increase in annual number of hospitalizations and duration of last-time hospitalization with the deterioration of hearing status in older adults. Actions should be taken to prevent and treat their hearing impairment, so as to decrease risk of hospitalization and improve their life quality.

show abstract

Progression of Hearing Loss in the Aging Population: Repeated Auditory Measurements in the Rotterdam Study

Cited by 45 publications

References 39 publications

Modeling Hearing Loss Progression and Asymmetry in the Older Old: A National Population‐Based Study

Modeling Hearing Loss Progression and Asymmetry in the Older Old: A National Population‐Based Study

Making the Case for Research on Disease-Modifying Treatments to Tackle Post-lingual Progressive Sensorineural Hearing Loss

Hearing status gradients in the risk of hospitalization among Chinese middle-aged and older adults

Contact Info

Product

Resources

About