Progression of gyrate atrophy measured with ultra-wide-field imaging

Abstract

The study aims to determine the progression of gyrate atrophy by measuring the area growth of chorioretinal atrophic lesions using ultra-wide-field images (UWFI). A retrospective, observational, and comparative study was conducted and UWFI (200°) were obtained from two patients with gyrate atrophy at baseline and follow-up. Measurements of atrophy were obtained for three types of lesions: Solitary atrophic lesions (SAL), De novo solitary lesions (DNSL), and peripapillary atrophy (PPA). Comparison of baseline and follow-up was done using t tests. Two patients with gyrate atrophy were included. Patient 1 presented 16 SAL, 5 DNSL, and PPA measured for both eyes (BE). Overall area growth (OAG) for SAL (expressed in decimals) presented a mean of 3.41, σ 3.07. DNSL area for BE presented a mean of 1586.08 P (2), σ 1069.55. OAG for PPA presented a mean of 1.21, σ 0.17. Patient 2 presented 5 SAL, no DNSL, and PPA was measured for BE. OAG for SAL presented a mean of 1.58, σ 1.05 (range 1.02-3.47). OAG for PPA presented a mean of 1.05, σ 0.001. Gyrate atrophy progression can be determined by measuring the changes in area using UWFI.

Gyrate Atrophy of the Choroid and Retina: A Review

“…50,51 The evaluation of GA can be also performed and followed up using ultra-widefield imaging which has been found to allow superior imaging of the peripheral retina simultaneously with the macula. 22,52 Electroretinography (ERG) may reveal diminished a and b wave responses from both cones and rods which may become undetectable in advanced disease, 53 however, a nearly normal ERG recording in association with GA has also been previously reported following long-term follow-up. 21 The electro-oculography and dark adaptometry are also frequently abnormal in patients with GA. 54 Visual field testing using both static and kinetic perimetry is useful in follow-up and shows progressive visual field affection and sensitivity loss with age which can, however, be slowed with appropriate treatment.…”

Structural evaluation in inherited retinal diseases

“…Red light improves visualisation of the choroid and its pattern; green light (red-free) is best for retinal vasculature, haemorrhages, drusen, exudates and the overall retina; and blue light is used to focus on the anterior retinal layers. 15 CFP, and particularly ultra-wide field CFP, is almost universally included as part of both standard-of-care and research visits for trials and studies in IRD, since it facilitates both documentation, evaluation and monitoring of for example, progression of areas of atrophy, 16 treated areas and retinotomy sites, inflammatory features including vasculitis, retinitis and choroiditis, 17 and is also valuable for teaching. CFP is frequently used for topographical tracking of functional tests, such as fundus-guided microperimetry, and moreover, can be used to overlay a wide array of functional assessments onto the retinal landscape.…”