Progression of Diabetic Nephropathy in Saudi Patients With Type 2 Diabetes Mellitus

Suleiman, M.; Kfoury, Hala; Jondeby, Mohamed; Burgos, Noel S.; Hayyan, Hajjar Al; Sayyari, Abdulla Al

doi:10.1097/ten.0b013e3181881611

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…Regarding hypertension the present findings is similar to that reported by Khan [8]. National records in SA and epidemiology studies showed high prevalence of diabetes incidence (DM) and high incidence of diabetic nephropathy (DN) among Saudi population El Minshawy and Al-Sayyari [9,10], Hassanien reported variability in prevalence of DN in different regions [11], Al Suleiman reported that Saudis with DN progress to ESRD faster than other population [12].…”

Section: Demographic and Etiology Characteristicssupporting

confidence: 88%

Therapeutic Drug Monitoring of Tacrolimus in Saudi Kidney Transplant Patients

Nasser¹,

Ali²,

Sattar³

et al. 2016

J Nephrol Ther

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Background: Tacrolimus is immunosuppressive agent used for the prevention of rejection in kidney transplant patients, has narrow therapeutic range, and variable pharmacokinetics. Objectives: To identify the optimum Tacrolimus blood trough level for Saudi kidney transplant patients (SKTP). Method: The research population consisted of 100 SKTP at the Armed Forces Hospital in the Southern Region (AFHSR) treated with Tacrolimus and followed-up for a period of 24 months (2012 till 2014). Results: A significant relationship between Tacrolimus trough level and incidence of kidney rejection was remarkably found only after 180 days post-transplantation. During this period, Tacrolimus mean trough level (ng/ml) was 7.4 ± 0.2 in SKTP with no rejection, 5.3 ± 0.7 for those with acute rejection, and 3.8 ± 0.4 for those with chronic rejection. Furthermore, the coefficient of variation (CV%) which reflects fluctuation in Tacrolimus trough level, was obviously high in SKTP with acute rejection in all post-kidney-transplant periods. Conclusion: After 6 month post-kidney transplantation in SKTP, Tacrolimus trough level (<5 ng/ml can lead to graft loss, great fluctuation in its level is a major risk factor in incidence of rejection. Further research at genetic level is needed to guide optimal dosing in the early period post transplantation.

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Section: Demographic and Etiology Characteristicssupporting

confidence: 88%

Therapeutic Drug Monitoring of Tacrolimus in Saudi Kidney Transplant Patients

Nasser¹,

Ali²,

Sattar³

et al. 2016

J Nephrol Ther

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Nephrology in Saudi Arabia

Sayyari

Rasheed

Hejaili

et al. 2021

Nephrology Worldwide

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Albuminuria, serum creatinine, and estimated glomerular filtration rate as predictors of cardio-renal outcomes in patients with type 2 diabetes mellitus and kidney disease: a systematic literature review

Norris¹,

Smoyer²,

Rolland³

et al. 2018

BMC Nephrol

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BackgroundAlbuminuria, elevated serum creatinine and low estimated glomerular filtration rate (eGFR) are pivotal indicators of kidney decline. Yet, it is uncertain if these and emerging biomarkers such as uric acid represent independent predictors of kidney disease progression or subsequent outcomes among individuals with type 2 diabetes mellitus (T2DM). This study systematically examined the available literature documenting the role of albuminuria, serum creatinine, eGFR, and uric acid in predicting kidney disease progression and cardio-renal outcomes in persons with T2DM.MethodsEmbase, MEDLINE, and Cochrane Central Trials Register and Database of Systematic Reviews were searched for relevant studies from January 2000 through May 2016. PubMed was searched from 2013 until May 2016 to retrieve studies not yet indexed in the other databases. Observational cohort or non-randomized longitudinal studies relevant to albuminuria, serum creatinine, eGFR, uric acid and their association with kidney disease progression, non-fatal cardiovascular events, and all-cause mortality as outcomes in persons with T2DM, were eligible for inclusion. Two reviewers screened citations to ensure studies met inclusion criteria.ResultsFrom 2249 citations screened, 81 studies were retained, of which 39 were omitted during the extraction phase (cross-sectional [n = 16]; no outcome/measure of interest [n = 13]; not T2DM specific [n = 7]; review article [n = 1]; editorial [n = 1]; not in English language [n = 1]). Of the remaining 42 longitudinal study publications, biomarker measurements were diverse, with seven different measures for eGFR and five different measures for albuminuria documented. Kidney disease progression differed substantially across 31 publications, with GFR loss (n = 9 [29.0%]) and doubling of serum creatinine (n = 5 [16.1%]) the most frequently reported outcome measures. Numerous publications presented risk estimates for albuminuria (n = 18), serum creatinine/eGFR (n = 13), or both combined (n = 6), with only one study reporting for uric acid. Most often, these biomarkers were associated with a greater risk of experiencing clinical outcomes.ConclusionsDespite the utility of albuminuria, serum creatinine, and eGFR as predictors of kidney disease progression, further efforts to harmonize biomarker measurements are needed given the disparate methodologies observed in this review. Such efforts would help better establish the clinical significance of these and other biomarkers of renal function and cardio-renal outcomes in persons with T2DM.Electronic supplementary materialThe online version of this article (10.1186/s12882-018-0821-9) contains supplementary material, which is available to authorized users.

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Progression of Diabetic Nephropathy in Saudi Patients With Type 2 Diabetes Mellitus

Cited by 4 publications

References 14 publications

Therapeutic Drug Monitoring of Tacrolimus in Saudi Kidney Transplant Patients

Therapeutic Drug Monitoring of Tacrolimus in Saudi Kidney Transplant Patients

Nephrology in Saudi Arabia

Albuminuria, serum creatinine, and estimated glomerular filtration rate as predictors of cardio-renal outcomes in patients with type 2 diabetes mellitus and kidney disease: a systematic literature review

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