Progression of Coronary Artery Disease (CAD) from Stable Angina (SA) Towards Myocardial Infarction (MI): Role of Oxidative Stress

Uppal, Neha; Uppal, Vibha; Uppal, Pankaj

doi:10.7860/jcdr/2014/7966.4002

Cited by 19 publications

(22 citation statements)

References 26 publications

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“…The results indicate that patients with ACS have significantly higher salivary MDA levels than healthy controls. This finding could be explained by previous reports suggesting that serum MDA be considered a biomarker for cardiovascular events 29 , 30 , 44 . Alternatively, many of the blood components are present in the saliva by passing through the spaces between cells.…”

Section: Discussionsupporting

confidence: 57%

“…LPO is one of the major consequences of OS and can be evaluated by monitoring the levels of malondialdehyde (MDA), a product of breaking down long carbon strings of fatty acid 22–25 . Previously, MDA levels have been assessed in the plasma, serum, gingival crevicular fluid, and saliva of patients with periodontitis, 14‐17,22‐28 as well as in the plasma and serum of patients with CHD 29 , 30 . However, to the best of the authors’ knowledge, no studies have been conducted to monitor salivary MDA levels in patients with ACS.…”

mentioning

confidence: 99%

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Salivary Lipid Peroxidation in Patients With Generalized Chronic Periodontitis and Acute Coronary Syndrome

Nguyễn

Ngo

Promsudthi

et al. 2016

Journal of Periodontology

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Section: Discussionsupporting

confidence: 57%

mentioning

confidence: 99%

Salivary Lipid Peroxidation in Patients With Generalized Chronic Periodontitis and Acute Coronary Syndrome

Nguyễn

Ngo

Promsudthi

et al. 2016

Journal of Periodontology

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“…Uppal et al noticed a significantly lower GSH level in the blood of patients with unstable angina and myocardial infarction, compared to stable angina patients and controls [18]. At the same time, the concentration of the final product of lipid peroxidation, malonyldialdehyde (MDA), was higher in UA and MI patients.…”

Section: Resultsmentioning

confidence: 98%

Glutathione level and glutathione reductase activity in serum of coronary heart disease patients

Zuzak¹,

Horecka²,

Kiełczykowska³

et al. 2017

J Pre Clin Clin Res.

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level and glutathione reductase activity in serum of coronary heart disease patients. J Pre-Clin Clin Res. 2017; 11(2): 103-105. doi: 10.26444/jpccr/81277 Abstract Introduction. Oxidative stress induced by the generation of excess reactive oxygen species is one of the cause of atherosclerosis finally leading to coronary heart disease (CHD). Glutathione reductase (GR), a flavoprotein antioxidant enzyme, regenerates glutathione (GSH) from its oxidized form, which is essential for scavenging of hydrogen peroxide by glutathione peroxidase. The aim of this study was to analyze the activity of GR and GSH level in serum of patients with various stages of CHD. Materials and method. Sixty consecutive patients with diagnosis of stable angina (SA, n=20), unstable angina (UA, n=20) and non-fatal myocardial infarction (MI, n=20) together with 20 healthy control subjects were enrolled. Venous blood samples were collected just before the coronary catheterization procedure (in study patients). GR activities and GSH concentration was determined using commercially available colorimetric kits. Results. The highest GR activity and GSH serum level was noticed in UA patients. However, statistical evaluation showed that only glutathione reductase activity was significantly higher in serum obtained from myocardial infarction patients, compared to stable angina pectoris patients (19.52 ± 13.88 vs 11.63 ± 5.45 nmol/min/ml for MI and SA, respectively; p<0.048). There were no significant differences in GSH between the CHD patients and controls. Conclusion. The elevated activity of glutathione reductase in serum of patients with unstable angina pectoris and myocardial infarction suggests the role of antioxidant system acute coronary syndromes.

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“…Since oxidative stress can lead to increased epidermal green AF by altering keratin 1 (12,13), the increased oxidative stress of AIS patients (2,6,23) and MI patients (1,5,11,15,24) may be responsible for the increased AF intensity. Our latest study has also indicated that inflammation can produced increased epidermal green AF intensity (26).…”

Section: Introductionmentioning

confidence: 99%

Green autofluorescence intensity of skin and fingernails: A novel biomarker for non-invasive evaluation of pathological state of blood vessels

Zhang

Tao

et al. 2018

Preprint

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Stroke and myocardial infarction (MI) are two leading causes of death around the world. It is of great significance to establish novel and non-invasive approaches for evaluating pathological state of blood vessels, so that early interventions may be carried out to prevent incidence of stroke or MI. Our recent studies have suggested that altered 'Pattern of Autofluorescence (AF)' of skin and fingernails are novel biomarkers of acute ischemic stroke (AIS) and MI. In particular, our studies have shown characteristic increases in the green AF intensity of the fingernails and certain regions of the skin of AIS patients and MI patients. By determining the skin's green AF of the Healthy Group, the Low-Risk Group for Developing AIS, and the High-Risk Group for Developing AIS, our current study has indicated that the green AF intensity in the right and left Ventroforefingers and Dorsal Antebrachium, the right Dorsal Centremetacarpus, Dorsal Index Fingers and Centremetacarpus, as well as the left Index Fingernails and Ventriantebrachium, is highly correlated with the risk of developing AIS. Our study has also suggested that oxidative stress and inflammation may account for the increased AF intensity in the Low-Risk Group and the High-Risk Group.These findings have suggested that the green AF intensity of the fingernails and certain regions of the skin is a novel biomarker for non-invasive evaluation of the injury levels of blood vessels and the risk of developing AIS or MI.

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Progression of Coronary Artery Disease (CAD) from Stable Angina (SA) Towards Myocardial Infarction (MI): Role of Oxidative Stress

Cited by 19 publications

References 26 publications

Salivary Lipid Peroxidation in Patients With Generalized Chronic Periodontitis and Acute Coronary Syndrome

Salivary Lipid Peroxidation in Patients With Generalized Chronic Periodontitis and Acute Coronary Syndrome

Glutathione level and glutathione reductase activity in serum of coronary heart disease patients

Green autofluorescence intensity of skin and fingernails: A novel biomarker for non-invasive evaluation of pathological state of blood vessels

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