Progression of bilateral morning glory syndrome associated with unilateral persistent fetal vasculture: A case report of long term follow-up in an infant

Abstract

Purpose To describe a case of Bilateral Morning Glory Syndrome (MGS) associated with Unilateral Persistent Fetal Vasculature (PFV) in a 3-day old neonate. Observations A 3-day-old neonate was found bilateral retinal abnormalities due to neonatal eye screening. Dilated fundus exam showed bilateral optic disc dysplasia with the persistent hyaloid vessels in right eye at first. With the progress of the disease, optic disc was enlarged with central umbilication which with a similar anomalous radiating peripapillary vascular appearance, the persistent hyaloid vessels in vitreous cavity of right eye gradually disappear, a large amount of exudation can be seen in the posterior pole retina with macular movement in both eyes. Bilateral vitrectomy was performed in this case, then the condition of the neonate's both eyes is stable until 1 year old. Conclusions and Importance This is a rare case that showing the development of MGS and PFV and the relationship between these two diseases. In addition, we completely observed the whole process of the change of the persistent hyaloid vessels in the vitreous cavity of a case of MGS associated with PFV.

Multimodal imaging of morning glory syndrome with persistent hyperplastic primary vitreous

“…Morning glory syndrome (MGS) is a rare congenital optic disc abnormity, which was named by Kindler in 1970, characterized by an enlarged optic disc with deep excavation and peripapillary pigmentation, a central glial tuft and radial retinal vessels 1 . It has been reported that the pathogenesis of MGS is associated with the maldevelopment of the lamina cribrosa and posterior sclera 2,3 …”

“…1 It has been reported that the pathogenesis of MGS is associated with the maldevelopment of the lamina cribrosa and posterior sclera. 2,3 Persistent hyperplastic primary vitreous (PHPV) is caused by the failure of regression of embryological primary vitreous and hyaloid vasculature. 4 Its characteristic is retrolental fibrovascular tissue, microphthalmia, retinal fold, intraocular hemorrhage, and lenticular opacification.…”