Progression of attachment loss is strongly associated with presence of the <scp>JP</scp>2 genotype of <i>Aggregatibacter actinomycetemcomitans</i>: a prospective cohort study of a young adolescent population

Åberg, Carola Höglund; Kwamin, Francis; Claesson, Rolf; Dahlén, Gunnar; Johansson, Anders; Haubek, Dorte

doi:10.1111/jcpe.12209

Cited by 67 publications

(115 citation statements)

References 45 publications

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“…The importance of the leukotoxicity of A. actinomycetemcomitans and its contribution to the pathogenesis have recently been shown in a study where young individuals (mean age 15.0 years) harbouring highly leukotoxic A. actinomycetemcomitans (of the JP2 and of the non-JP2 genotypes) had a significantly increased risk for progression of localized periodontal attachment loss during a 2 y follow-up period. 23 A strong correlation between highly leukotoxic strains of A. actinomycetemcomitans and periodontitis has also been reported in Brazilian populations. 65 Different ethnic populations seem to show highly variable frequency of the JP2 clonal type of A. actinomycetemcomitans.…”

Section: 33mentioning

confidence: 92%

“…18 Prospective population-based studies have shown that individuals infected by strains of the serotype b JP2 genotype of A. actinomycetemcomitans have a significantly higher risk of developing AgP than individuals infected by strains of the non-JP2 genotype. 17,23 The JP2 genotype is defined by a 530-bp deletion in the promoter region of the leukotoxin operon, and this genotype is highly leukotoxic. 24 The within-species variable virulence of A. actinomycetemcomitans may be attributed to strainto-strain variation in the genome content and in the regulation of virulence gene expressions.…”

Section: Aggregatibacter Actinomycetemcomitansmentioning

confidence: 99%

“…35 There is a strong association between the presence of highly leukotoxic A. actinomycetemcomitans, both of the JP2-genotype and some highly leukotoxic variants of the non-JP2 genotype, and the disease progression in the infected individuals studied. 17,23,26 These findings attract enhanced attention concerning the importance of leukotoxicity acting toward the defense mechanisms in the host response.…”

Section: Aggregatibacter Actinomycetemcomitansmentioning

confidence: 99%

“…17,21,23,63,64 Disease development in terms of progression of attachment loss has been evaluated prospectively among adolescents 17,21,23 in relation to the carrier status of A. actinomycetemcomitans. In a recently followed West African cohort there was a significantly increased risk (OR=5 .126, 95% CI [2.994 -8.779] P <0.001) for progression of attachment loss among the A. actinomycetemcomitans-positive young individuals as compared with the A. actinomycetemcomitans-negative reference individuals.…”

Section: A Actinomycetemcomitans In the Pre-clinical Phase Of Aggresmentioning

confidence: 99%

“…66,67 This specific genotype of A. actinomycetemcomitans significantly correlates to periodontal disease onset in infected individuals of African origin. 17,23,68 Subjects harboring highly leukotoxic A. actinomycetemcomitans are reported to be 18 times more likely to convert from a healthy status to localized aggressive periodontitis than those colonized by strains harboring the full-length leukotoxin promoter region. 17 However, there is also convincing evidence that phylogenetically diverse strains of A. actinomycetemcomitans of the non-JP2 genotype can carry pathogenic potential.…”

Section: 33mentioning

confidence: 99%

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Aggregatibacter actinomycetemcomitans: Virulence of its leukotoxin and association with aggressive periodontitis

2014

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Section: 33mentioning

confidence: 92%

Section: Aggregatibacter Actinomycetemcomitansmentioning

confidence: 99%

Section: Aggregatibacter Actinomycetemcomitansmentioning

confidence: 99%

Section: A Actinomycetemcomitans In the Pre-clinical Phase Of Aggresmentioning

confidence: 99%

Section: 33mentioning

confidence: 99%

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Aggregatibacter actinomycetemcomitans: Virulence of its leukotoxin and association with aggressive periodontitis

2014

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High salivary levels of JP2 genotype of Aggregatibacter actinomycetemcomitans is associated with clinical attachment loss in Moroccan adolescents

Ennibi

Claesson

Akkaoui

et al. 2019

Clinical & Exp Dental Res

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It has previously been shown that the presence of Aggregatibacter actinomycetemcomitans in subgingival plaque is significantly associated with increased risk for clinical attachment loss. The highly leukotoxic JP2 genotype of this bacterium is frequently detected in adolescents with aggressive forms of periodontitis. The aims of the study were to quantify the levels of JP2 and non‐JP2 genotypes of A. actinomycetemcomitans in saliva of Moroccan adolescents with the JP2 genotype earlier detected in the subgingival plaque. The salivary concentrations of inflammatory proteins were quantified and linked to the clinical parameters and microbial findings. Finally, a mouth rinse with leukotoxin‐neutralizing effect was administrated and its effect on the levels the biomarkers and A. actinomycetemcomitans examined. The study population consisted of 22 adolescents that previously were found to be positive for the JP2 genotype in subgingival plaque. Periodontal registration and sampling of stimulated saliva was performed at baseline. A mouth rinse (active/placebo) was administrated, and saliva sampling repeated after 2 and 4 weeks rinse. The salivary levels of JP2 and non‐JP2 were analyzed by quantitative PCR and inflammatory proteins by ELISA. Both the JP2 and the non‐JP2 genotype were detected in all individuals with significantly higher levels of the non‐JP2. Enhanced levels of the JP2 genotype of A. actinomycetemcomitans was significantly correlated to the presence of attachment loss (≥3 mm). Salivary concentrations of inflammatory biomarkers did not correlate to periodontal condition or levels of A. actinomycetemcomitans . The use of active or placebo leukotoxin‐neutralizing mouth rinse did not significantly interfered with the levels of these biomarkers. Saliva is an excellent source for detection of A. actinomycetemcomitans on individual basis, and high levels of the JP2 genotype were significantly associated with the presence of clinical attachment loss.

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Alveolar bone resorption and Th1/Th17‐associated immune response triggered during Aggregatibacter actinomycetemcomitans‐induced experimental periodontitis are serotype‐dependent

Monasterio

Castillo

Ibarra

et al. 2018

Journal of Periodontology

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Progression of attachment loss is strongly associated with presence of the JP2 genotype of Aggregatibacter actinomycetemcomitans: a prospective cohort study of a young adolescent population

Abstract: The JP2 genotype of A. actinomycetemcomitans is strongly associated with the progression of AL.

Cited by 67 publications

References 45 publications

Aggregatibacter actinomycetemcomitans: Virulence of its leukotoxin and association with aggressive periodontitis

Aggregatibacter actinomycetemcomitans: Virulence of its leukotoxin and association with aggressive periodontitis

High salivary levels of JP2 genotype of Aggregatibacter actinomycetemcomitans is associated with clinical attachment loss in Moroccan adolescents

Alveolar bone resorption and Th1/Th17‐associated immune response triggered during Aggregatibacter actinomycetemcomitans‐induced experimental periodontitis are serotype‐dependent

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