Progression of atherosclerosis after venous coronary artery bypass graft surgery: A 15-year follow-up study

Brussel, Ben L. van; Plokker, H.W. Thijs; Voors, Adriaan A.; Ernst, Sjef M.P.G.; Kelder, Hans

doi:10.1002/(sici)1097-0304(199706)41:2<141::aid-ccd8>3.0.co;2-7

Cited by 18 publications

(8 citation statements)

References 26 publications

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“…Our findings show that greater SVG LCBI is seen in patients with greater annual total cholesterol exposure as bypass grafting, and greater maxLCBI 4 mm is seen in patients with greater annual LDL‐C and triglyceride exposure. The association between higher triglyceride exposure and LCP is consistent with the previously described relationship between hypertriglyceridemia and late myocardial infarction following bypass grafting . Zhu et al calculated annualized lipid exposure for 436 SVGs and showed that graft failure was associated with increased total cholesterol/HDL‐C and LDL‐C/HDL‐C exposure .…”

Section: Discussionsupporting

confidence: 83%

Saphenous vein graft near‐infrared spectroscopy imaging insights from the lipid core plaque association with clinical events near‐infrared spectroscopy (ORACLE‐NIRS) registry

Danek

Karatasakis

Alame

et al. 2016

Cathet Cardio Intervent

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Objectives We sought to examine near-infrared spectroscopy (NIRS) imaging findings of aortocoronary saphenous vein grafts (SVGs). Background SVGs are prone to develop atherosclerosis similar to native coronary arteries. They have received little study using NIRS. Methods We examined the clinical characteristics and imaging findings from 43 patients who underwent NIRS imaging of 45 SVGs at our institution between 2009 and 2016. Results The mean patient age was 67 ± 7 years and 98% were men, with high prevalence of diabetes mellitus (56%), hypertension (95%), and dyslipidemia (95%). Mean SVG age was 7 ± 7 years, mean SVG lipid core burden index (LCBI) was 53 ± 60 and mean maxLCBI4mm was 194 ± 234. Twelve SVGs (27%) had lipid core plaques (2 yellow blocks on the block chemogram), with a higher prevalence in SVGs older than 5 years (46% vs. 5%, p=0.002). Older SVG age was associated with higher LCBI (r=0.480, p<0.001) and higher maxLCBI4mm (r=0.567, p<0.001). On univariate analysis, greater annual total cholesterol exposure was associated with higher SVG LCBI (r=0.30, p=0.042) and annual LDL-cholesterol and triglyceride exposure were associated with higher SVG maxLCBI4mm (LDL-C: r=0.41, p=0.020; triglycerides: r=0.36, p=0.043). On multivariate analysis, the only independent predictor of SVG LCBI and maxLCBI4mm was SVG age. SVG percutaneous coronary intervention was performed in 63% of the patients. An embolic protection device was used in 96% of SVG PCIs. Periprocedural myocardial infarction occurred in one patient. Conclusions Older SVG age and greater lipid exposure are associated with higher SVG lipid burden.

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Section: Discussionsupporting

confidence: 83%

Saphenous vein graft near‐infrared spectroscopy imaging insights from the lipid core plaque association with clinical events near‐infrared spectroscopy (ORACLE‐NIRS) registry

Danek

Karatasakis

Alame

et al. 2016

Cathet Cardio Intervent

View full text Add to dashboard Cite

show abstract

“…Our findings show that greater SVG LCBI is seen in patients with greater annual total cholesterol exposure as bypass grafting, and greater maxLCBI 4 mm is seen in patients with greater annual LDL-C and triglyceride exposure. The association between higher triglyceride exposure and LCP is consistent with the previously described relationship between hypertriglyceridemia and late myocardial infarction following bypass grafting [30]. Zhu et al calculated annualized lipid exposure for 436 SVGs and showed that graft failure was associated with increased total cholesterol/HDL-C and LDL-C/ HDL-C exposure [21].…”

Section: E176supporting

confidence: 83%

Long-term follow-up after near-infrared spectroscopy coronary imaging: Insights from the lipid cORe plaque association with CLinical events (ORACLE-NIRS) registry

Danek

Karatasakis

Karácsonyi

et al. 2017

Cardiovascular Revascularization Medicine

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“…However, covariates for which we have found no association with outcome may have a weaker association than we are able to detect. For example, the adverse effect on survival of patients with more extensive preoperative coronary artery disease is well described,26 34 39 and compared with older patients, a survival advantage has been reported in younger patients which persisted with prolonged periods of follow up 2734We estimate that the smallest detectable difference in total mortality between the upper and lower tertiles of the laboratory variables represents a relative risk of approximately 2.0.…”

Section: Discussionmentioning

confidence: 99%

High apolipoprotein AI concentrations are associated with lower mortality and myocardial infarction five years after coronary artery bypass graft surgery

Skinner

Farrer

Albers

et al. 1999

Heart

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Objective-To examine mortality and myocardial infarction five years after coronary artery bypass graft (CABG) surgery and the association with diVerent lipid fractions and haemostatic, glycaemic, and demographic risk factors. Setting-A regional cardiothoracic centre, Freeman Hospital, and the University Clinical Investigation Unit, Royal Victoria Infirmary, Newcastle upon Tyne, UK. Design-353 consecutive patients (297 male, mean age 57.2 years) undergoing first time CABG for stable angina were recruited to a prospective cohort study and studied to five years. Main outcome measures-All cause mortality, late cardiac mortality (beyond 30 days) alone and in combination with nonfatal myocardial infarction. Risk factor assessments before operation and 3, 6, 12, 24, and 60 months after surgery. For each laboratory variable a weighted mean for the period of exposure was calculated from the concentration at each time interval and the time between measurements. The distribution was divided into tertiles. Results-41 patients died (16 late cardiac deaths) and eight had a myocardial infarct. An adverse outcome occurred more frequently in the lower tertile of weighted apolipoprotein AI compared with the upper tertile. An adverse outcome was also more common in patients in the upper tertile of weighted total white blood cell count and less consistently so in patients in the upper tertile of the haemostatic covariates, factor VIIc and factor VIIIc. There was no association with other lipid fractions except for total mortality and apolipoprotein B (owing to low levels in five patients with carcinoma). Conclusions-Low apolipoprotein AI concentrations, but no other markers of an adverse lipid profile, were associated with mortality and myocardial infarction five years after CABG. Apolipoprotein AI is associated with paraoxonase, an enzyme located on high density lipoprotein, which may limit the oxidation of low density lipoprotein. An association between outcome and other covariates such as white cell count provides a credible pointer to inflammation mediating a component of cardiovascular risk. (Heart 1999;81:488-494)

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Progression of atherosclerosis after venous coronary artery bypass graft surgery: A 15-year follow-up study

Cited by 18 publications

References 26 publications

Saphenous vein graft near‐infrared spectroscopy imaging insights from the lipid core plaque association with clinical events near‐infrared spectroscopy (ORACLE‐NIRS) registry

Saphenous vein graft near‐infrared spectroscopy imaging insights from the lipid core plaque association with clinical events near‐infrared spectroscopy (ORACLE‐NIRS) registry

Long-term follow-up after near-infrared spectroscopy coronary imaging: Insights from the lipid cORe plaque association with CLinical events (ORACLE-NIRS) registry

High apolipoprotein AI concentrations are associated with lower mortality and myocardial infarction five years after coronary artery bypass graft surgery

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