Progression of Aortic Stenosis

Natural Evolution of Aortic Valve Regurgitation Following Surgery for Rheumatic Mitral Valve Disease

“…These observations had been reported by other investigations [24][25][26] Otto and al [27] found that 75% of patients with mild AS develop symptoms 5 years after mitral valve surgery.…”

Calcific degeneration of the aortic valve in old age: is the development of flow obstruction predictable

“…So far, all reports on serial assessment of aortic valve function have focused on patients with established aortic valve stenosis ; no studies in unselected elderly individuals exist for comparison. The earliest follow-up investigations were based on repeated cardiac catheterizations [16][17][18][19][20][21][22][23] and showed a progressive reduction of aortic valve area ranging from 0n02 to 0n3 cm# per year on average. However, the study groups were small, from 11 to maximally 65 patients, and with mean ages from 37 to 61 years, much younger than ours.…”

Sequential study of left ventricular function in aortic valvular stenosis

“…From our 16 patients with increased AVG, the average rate of progression of the aortic gradient was 10.3 mm Hg/year, but it was quite variable and unpredictable. Bogart et a1 [15], and Cheitlin et al [16], reported a similar variability of progression of AVG. The pronounced delay of upstroke time may well suggest the increasing AVG as other investigators [6,7,10] have experienced, but it was not helpful in some cases and the magnitude of the delay of upstroke time did not correlate with the change of AVG.…”

“…Various noninvasive techniques such as the degree of valve calcification [6, 71, electrovectorcardiography [8,9, 141, phonocardiographic parameters [6,7, lo], echocardiography [ll-131, and kinetocardiography [7] have been utilized to assess the severity of aortic stenosis, but none of these provides a definite guide for determining the transvalvular aortic gradient. The serial measurements of aortic valvular gradients (AVG) by catheterization in adult patients were recently reported by several authors [15][16], but to our knowledge the serial evaluation of left ventricular function has not been reported, although Kennedy et a1 [17] and Liedtke et a1 [18] demonstrated the impaired left ventricular function in patients with aortic stenosis.…”