Progression of anemia and its relationship with renal function, blood pressure, and erythropoietin in rats with chronic kidney disease

Phillips, Jacqueline K.; Boyd, Rochelle; Krockenberger, M. B.; Burgio, Gaétan

doi:10.1111/vcp.12276

Cited by 12 publications

(10 citation statements)

References 43 publications

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“…This leukocytosis was related to the stress state and its influence on the immune system. These results are in accordance with previous reports in mice 46,47 or neonates 17 treated with Pb. Similar observations were also made in ruminant and non-ruminant animals.…”

Section: Discussionsupporting

confidence: 94%

Protective effects of spirulina against hemato-biochemical alterations, nephrotoxicity, and DNA damage upon lead exposition

et al. 2020

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The current study was aimed at exploring the protective efficacy of spirulina against the hemato-biochemical alterations and nephrotoxicity induced by lead (Pb). Female rats aged 12 weeks were treated for 4 weeks with Pb (0.344 g kg−1 bw) associated or not with spirulina (5.3 g kg−1 bw). Renal damage induced by Pb was related to a severe anemia, increases of oxidative stress-related parameters (thiobarbituric acid reactive substances (TBARS) (+29%), protein carbonyl (PCO) (+66.3%), and advanced oxidation protein product (AOPP) (+110%)), plasma lactate dehydrogenase (LDH) (+80%), creatinine and urea levels in plasma, and uric acid concentration in urine, as well as genotoxic changes (+89.3% and +60% for DNA and mRNA levels, respectively). Conversely, LDH and antioxidant enzyme activities in kidney were decreased, as well as the levels of plasma uric acid, and urinary creatinine and urea levels. Spirulina-supplemented rats exhibited normal peripheral blood and renal parameters and renal histology. It can be suggested that Arthrospira platensis alleviates damages induced by Pb, thanks to its high phenolic content and antioxidant capacity.

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Section: Discussionsupporting

confidence: 94%

Protective effects of spirulina against hemato-biochemical alterations, nephrotoxicity, and DNA damage upon lead exposition

et al. 2020

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“…Both patients showed severe chronic renal diseases. Blood analysis (rise in urea and creatinine values as well as anemia) and urinalysis confirmed the suspicion . Unfortunately, no urine reference values for glucose or pH values are stated for common marmosets.…”

Section: Discussionmentioning

confidence: 82%

Blood pressure as prognostic marker for body condition, cardiovascular, and metabolic diseases in the common marmoset (Callithrix jacchus)

Mietsch

Baldauf

Reitemeier

et al. 2016

J of Medical Primatology

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“…Phenotypic data including bodyweight, systolic blood pressure (SBP), heart, left ventricle and kidney indices (tissue weight (g)/body weight (g) × 100%) and plasma analysis for urea and creatinine was determined for these animals. To facilitate tissue sharing and reduction in animal usage, some data from animals in this cohort (SBP, plasma urea and creatinine) contributed to another larger study correlating these variables with anaemia measures in the LPK model (Phillips et al, in press ). (iii) 12- and 18-week-old LPK ( n = 9 each age), and 12- and 18-week-old Lewis rats ( n = 16 and 12, respectively) were used for aortic Ca +2 content analysis.…”

Section: Methodsmentioning

confidence: 99%

Abnormalities associated with progressive aortic vascular dysfunction in chronic kidney disease

et al. 2015

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Increased stiffness of large arteries in chronic kidney disease (CKD) has significant clinical implications. This study investigates the temporal development of thoracic aortic dysfunction in a rodent model of CKD, the Lewis polycystic kidney (LPK) rat. Animals aged 12 and 18 weeks were studied alongside age-matched Lewis controls (total n = 94). LPK rodents had elevated systolic blood pressure, left ventricular hypertrophy and progressively higher plasma creatinine and urea. Relative to Lewis controls, LPK exhibited reduced maximum aortic vasoconstriction (Rmax) to noradrenaline at 12 and 18 weeks, and to K+ (12 weeks). Sensitivity to noradrenaline was greater in 18-week-old LPK vs. age matched Lewis (effective concentration 50%: 24 × 10−9 ± 78 × 10−10 vs. 19 × 10−8 ± 49 × 10−9, P < 0.05). Endothelium-dependent (acetylcholine) and -independent (sodium nitroprusside) relaxation was diminished in LPK, declining with age (12 vs. 18 weeks Rmax: 80 ± 8% vs. 57 ± 9% and 92 ± 6% vs. 70 ± 9%, P < 0.05, respectively) in parallel with the decline in renal function. L-Arginine restored endothelial function in LPK, and L-NAME blunted acetylcholine relaxation in all groups. Impaired nitric oxide synthase (NOS) activity was recovered with L-Arginine plus L-NAME in 12, but not 18-week-old LPK. Aortic calcification was increased in LPK rats, as was collagen I/III, fibronectin and NADPH-oxidase subunit p47 (phox) mRNAs. Overall, our observations indicate that the vascular abnormalities associated with CKD are progressive in nature, being characterized by impaired vascular contraction and relaxation responses, concurrent with the development of endothelial dysfunction, which is likely driven by evolving deficits in NO signaling.

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Progression of anemia and its relationship with renal function, blood pressure, and erythropoietin in rats with chronic kidney disease

Abstract: Marked anemia in the LPK CKD rodent model in the presence of elevated EPO suggests inefficient erythropoiesis that is correlated with plasma urea concentration and blood pressure.

Cited by 12 publications

References 43 publications

Protective effects of spirulina against hemato-biochemical alterations, nephrotoxicity, and DNA damage upon lead exposition

Protective effects of spirulina against hemato-biochemical alterations, nephrotoxicity, and DNA damage upon lead exposition

Blood pressure as prognostic marker for body condition, cardiovascular, and metabolic diseases in the common marmoset (Callithrix jacchus)

Abnormalities associated with progressive aortic vascular dysfunction in chronic kidney disease

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