Progression in acute ischemic stroke: Is widespread atherosclerotic background a risk factor?

Abstract

Objectives:In this study, we aimed to investigate the causes and conditions related with progression and outcome of progressive acute ischemic stroke. Patients and methods:In this prospective study, a total of 78 acute ischemic stroke patients (32 males, 46 females; mean age 70±12.8 years; range 34 to 95 years) were included between February 2006 and October 2010. The patients were classified into two groups as those with and without progression according to the National Institute of Health Stroke Scale (NIHSS). Risk factors for ischemic stroke, stroke subtypes, and radiological investigations and prognosis were compared between the progressive and non-progressive patients.Results: Neurological deterioration occurred in 12 patients (15%). Progressive acute ischemic stroke patients had carotid stenosis compared to non-progressive patients (50% vs 19%), and ischemic cardiac disease (33% vs 6%) more common in the patients with progression. Mortality during hospital stay and long term-outcomes were similar between the groups. Conclusion:Our study results suggest that widespread atherosclerotic diseases may induce neurological progression.

The effect of craniocervical atherosclerotic stenosis on the occurence of neurologic deterioration of patients with small vessel occlusion stroke and their clinical outcomes

“…However, these two studies did not analyze the effect of the craniocervical AS on the occurrence of ND in their study subjects. Several works found that craniocervical atherosclerotic conditions were correlated with the occurrence of ND in patients with ischemic stroke (14,23,24) , thus we further analyzed the relationship of the craniocervical AS with the occurrence of ND in patients with SVO stroke in the present study. We demonstrated that both the presence and the number of craniocervical AS are predictors of ND in patients with SVO stroke.…”

Factors associated with an increased risk of developing pneumonia during acute ischemic stroke hospitalization

“…The impact of pneumonia on the results of treatment, including post-stroke complications, length of stay, status at discharge, and 3-month mRS and BI scores, was also investigated. For stroke complications, progressive stroke was defined as the gradual worsening of neurological function (NIHSS score increase �4) during the 72 hours after stroke onset from an ongoing ischemic process [35][36][37][38][39][40]; brain edema was diagnosed when the patient had a new neurological deficit from brain swelling that was seen in a brain image [41]; and symptomatic intracranial hemorrhage was defined as any intracranial hemorrhage with neurologic deterioration, as indicated by an NIHSS score of �4 points higher than the baseline value [42]. The characteristics of all patients who developed SAP were examined in detail.…”

An Integrated Metabolomic Screening Platform Discovers the Potential Biomarkers of Ischemic Stroke and Reveals the Protective Effect and Mechanism of Folic Acid

“…With more than 800,000 cases occurring every year, stroke has become the fifth leading cause of death in the United States ( Feigin et al, 2016 ; Jamthikar et al, 2021 ). Among them, ischemic stroke (IS) is the most common type of stroke accounting for 87%, which caused irreversible damage through a variety of cerebral blood supply disorders to the local brain tissue ( Sümer and Özön, 2017 ; Du et al, 2020 ; Qin et al, 2020 ; Tan et al, 2020 ; Salazar-Camelo et al, 2021 ). In clinical practice, conventional treatment measures, such as oxygen inhalation, controlling infection, and lowering intracranial pressure, and specialized treatments, such as early thrombolysis, antiplatelet, anticoagulation, and defibrosis, have certain neurological side effects ( Amr et al, 2016 ; Sarmiento et al, 2019 ; Cheng et al, 2020 ; Herpich and Rincon, 2020 ; Hill, 2020 ).…”