Progression and regression of left ventricular hypertrophy and myocardial fibrosis in a mouse model of hypertension and concomitant cardiomyopathy

Kwieciński, Jacek; Lennen, Ross J.; Gray, Gillian A.; Borthwick, Gary; Boswell, Lyndsey; Baker, Andrew H.; Newby, David E.; Dweck, Marc R; Jansen, Maurits A.

doi:10.1186/s12968-020-00655-7

Cited by 25 publications

(34 citation statements)

References 32 publications

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“…AST is highly active in the cytosol of myocardial tissue compared with serum, and its measurable values in the blood are expected to increase after fibrosis, which may occur in the presence of SVH [29]. Myocardial fibrosis is observed in multiple cardiac conditions including HT and aortic stenosis [30]. As a result of our study, LVMI and AST values were found to be significantly higher in the non-dipper pattern group compared with the normotensive and dipper BP pattern groups.…”

Section: Discussionmentioning

confidence: 47%

Fibrosis-4 index: A new marker to predict non-dipper blood pressure pattern in patients with newly diagnosed hypertension

Küçük¹,

Arslan²

2022

Iberoam J Med

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Introduction: Epicardial fat tissue (EFT) is a significant risk factor for cardiovascular diseases. This study aimed to investigate whether there is a relationship between the fibrosis-4 index (FIB-4 index) and EFT in newly-diagnosed hypertensive patients and explore the usability of the FIB-4 index in predicting non-dipper blood pressure (BP) pattern. Materials and methods: Our case–control study consisted of 210 patients in 3 groups according to BP values, namely normotensive, dipper, and non-dipper groups. Transthoracic echocardiography and 24-h ambulatory BP monitoring were performed in all patients. Results: The median FIB-4 index was higher in the non-dipper group [1.56 (1.10-2)] than in the dipper [1 (0.71-1.32)] and normotensive groups [0.96 (0.69-1.32)] (p < 0.001, for both). A positive correlation was observed between EFT and the FIB-4 index (r=0.389, p<0.001). In multivariate logistic regression analysis, EFT (odds ratio (OR): 0.506, 95% confidence interval (CI): 1.288-2.135; p<0.001) and FIB-4 index (OR: 1.099, 95% CI: 1.621–5.556; p<0.001) were found to be independent predictors of non-dipper BP. In the receiver operating characteristic curve analysis, the FIB-4 index had 68% sensitivity and 72% specificity at a value >1.25 (area under the curve: 0.751, 95%CI: 0.679-0.823, p<0.001). Conclusions: In newly-diagnosed hypertensive people, the FIB-4 index is related to non-dipper BP patterns. FIB-4 index appears to be a helpful tool in assessing risk associated with cardiovascular disease.

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Section: Discussionmentioning

confidence: 47%

Fibrosis-4 index: A new marker to predict non-dipper blood pressure pattern in patients with newly diagnosed hypertension

Küçük¹,

Arslan²

2022

Iberoam J Med

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“…Previous studies have found that Ang II cause hypertension and hypertensive cardiac hypertrophy and fibrosis. 23 , 24 SIRT3 can protect the heart from multiple types of diseases which cause cardiac hypertrophy and fibrosis, through the regulation of oxidative stress, metabolism and aging. 14 , 25 , 26 , 27 It was consistent with the previous study that SIRT3 deficiency aggravated Ang II‐induced heart injury.…”

Section: Discussionmentioning

confidence: 99%

Sirtuin 3 deficiency aggravates angiotensin II‐induced hypertensive cardiac injury by the impairment of lymphangiogenesis

Zhang¹,

Li²,

Suo³

et al. 2021

J Cellular Molecular Medi

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Lymphangiogenesis is possibly capable of attenuating hypertension‐induced cardiac injury. Sirtuin 3 (SIRT3) is an effective mitochondrial deacetylase that has the potential to modulate this process; however, its role in hypertension‐induced cardiac lymphangiogenesis to date has not been investigated. Our experiments were performed on 8‐week‐old wild‐type (WT), SIRT3 knockout (SIRT3‐KO) and SIRT3 overexpression (SIRT3‐LV) mice infused with angiotensin II (Ang II) (1000 ng/kg per minute) or saline for 28 days. After Ang II infusion, SIRT3‐KO mice developed a more severe cardiac remodelling, less lymphatic capillaries and lower expression of lymphatic marker when compared to wild‐type mice. In comparison, SIRT3‐LV restored lymphangiogenesis and attenuated cardiac injury. Furthermore, lymphatic endothelial cells (LECs) exposed to Ang II in vitro exhibited decreased migration and proliferation. Silencing SIRT3 induced functional decrease in LECs, while SIRT3 overexpression LECs facilitated. Moreover, SIRT3 may up‐regulate lymphangiogenesis by affecting vascular endothelial growth factor receptor 3 (VEGFR3) and ERK pathway. These findings suggest that SIRT3 could promote lymphangiogenesis and attenuate hypertensive cardiac injury.

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“…Myocardial brosis is commonly associated with cardiac hypertrophy and failure and is associated with worsening ventricular systolic function, abnormal cardiac remodeling, and increased ventricular stiffness in animal models [20]. Although endocardial biopsy is the most speci c procedure for measuring myocardial brosis, it is invasive, and its sensitivity is low due to sampling errors [21].…”

Section: Discussionmentioning

confidence: 99%

Left Ventricular Myocardial T1 Values and Extracellular Volume Fraction in Asymptomatic Subjects: Variations According to Left Ventricular Segments and Correlation with Cardiovascular Risk Factors

Kim

Cho

Kim

et al. 2021

Preprint

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Purpose: To evaluate the normal range and variation in pre-contrast (preT1) and post-contrast (postT1) myocardial T1 values and extracellular volume fraction (ECV) according to left ventricular (LV) segments and to check for correlations between them and known cardiovascular risk factors.Methods: This study included 233 asymptomatic subjects (210 men and 23 women; aged 54.1±6.0 years) who underwent cardiac magnetic resonance imaging with preT1 and postT1 mapping on a 1.5-T scanner. T1 values and ECVs were compared among LV segments, age groups, and sex, and correlated with renal function. Based on the presence of hypertension (HTN) and diabetes mellitus (DM), the subjects were subdivided into the control (n=121), HTN (n=58), DM (n=25), and HTN and DM (HTN-DM) groups (n=29).Results: T1 values and ECV showed significant differences between the basal septal and lateral segments (p≤0.001) and between the mid-septal and mid-lateral segments (PreT1 p≤0.003, postT1 and ECV p<0.001). Among subgroups according to the HTN and DM status, the HTN-DM group showed a significantly higher ECV (0.260±0.023) than the control (0.240±0.021, p=0.011) and HTN (0.241±0.024, p=0.041) groups. Overall postT1 and ECV of the LV had significant correlation with the estimated glomerular filtration rate (r = 0.19, p=0.038 for postT1; r = -0.23, p=0.011 for ECV).Conclusion: Septal segments show higher preT1 and ECV but lower postT1 than lateral segments at the mid-ventricular and basal levels. ECV is significantly affected by cardiovascular risk factors such as HTN, DM, and decreased renal function, even in asymptomatic subjects.

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Progression and regression of left ventricular hypertrophy and myocardial fibrosis in a mouse model of hypertension and concomitant cardiomyopathy

Cited by 25 publications

References 32 publications

Fibrosis-4 index: A new marker to predict non-dipper blood pressure pattern in patients with newly diagnosed hypertension

Fibrosis-4 index: A new marker to predict non-dipper blood pressure pattern in patients with newly diagnosed hypertension

Sirtuin 3 deficiency aggravates angiotensin II‐induced hypertensive cardiac injury by the impairment of lymphangiogenesis

Left Ventricular Myocardial T1 Values and Extracellular Volume Fraction in Asymptomatic Subjects: Variations According to Left Ventricular Segments and Correlation with Cardiovascular Risk Factors

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