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Cited by 2 publications
(1 citation statement)
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“…Then the Center for Food Safety and Applied Nutrition classified acrylamide as carcinogenic and neurotoxic to humans [2], where acrylamide double bond is an electrophilic centre, and consequently it can easily react with nucleophilic groups, consequently, it is possible to covalently bond in vivo to cellular nucleophiles [3]. Moreover, acrylamide has been found to be readily absorbed by the skin and mucosa and diffuse strongly into tissues and fetus [4]. This acrylamide was thought to be formed in foods as a result of reaction between asparagine (an amino acid) and carbonylcontaining compound such as reducing sugars at higher temperatures and low moisture conditions, via Schiff base formation, followed by decarboxylation and imine elimination, such mechanism was confirmed by using of isotopic substitution [5].…”
Section: Introductionmentioning
confidence: 99%
“…Then the Center for Food Safety and Applied Nutrition classified acrylamide as carcinogenic and neurotoxic to humans [2], where acrylamide double bond is an electrophilic centre, and consequently it can easily react with nucleophilic groups, consequently, it is possible to covalently bond in vivo to cellular nucleophiles [3]. Moreover, acrylamide has been found to be readily absorbed by the skin and mucosa and diffuse strongly into tissues and fetus [4]. This acrylamide was thought to be formed in foods as a result of reaction between asparagine (an amino acid) and carbonylcontaining compound such as reducing sugars at higher temperatures and low moisture conditions, via Schiff base formation, followed by decarboxylation and imine elimination, such mechanism was confirmed by using of isotopic substitution [5].…”
Section: Introductionmentioning
confidence: 99%