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<p>Molnupiravir (MK-4482, EIDD-2801) is a promising orally bioavailable drug candidate for
treatment of COVID-19. Herein we describe a supply-centered and chromatography-free synthesis
of molnupiravir from cytidine, consisting of two steps: a selective enzymatic acylation followed
by transamination to yield the final drug product. Both steps have been successfully performed on
decagram scale: the first step at 200 g, and the second step at 80 g. Overall, mo… Show more
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