Progress toward Understanding Vascular Malformations

Breugem, Corstiaan C.; Horst, Chantal M.A.M. van der; Hennekam, Raoul C. M.

doi:10.1097/00006534-200105000-00033

Cited by 55 publications

(21 citation statements)

References 137 publications

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“…6 It is evident that transforming growth factor-b is involved in the induction of apoptotic endothelial cell death. 7 There is also research to support the idea that a reduced apoptotic process may cause the dysregulation of vascular growth in AVMs. 8 It is interesting that AVMs are much more prevalent in the central nervous system than elsewhere because neurons, having lost the ability to multiply, rarely undergo apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Arteriovenous Malformation of Tongue: A Case Report and Review of Literature

Pujari

Bahirwani

Balaji

et al. 2011

JIAOMR

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The intracranial arterial or AVMs most commonly present in the head and neck region are usually overlooked when present at birth owing to their innocent appearance. Associated important clinical signs are warmth a palpable thrill and a bruit. They may also be associated with complications, like ischemic changes, indolent ulceration, pain and bleeding. Here, we present a case of AVM of tongue in a 27-year-old male patient which was diagnosed based upon his oral lesions.

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Section: Discussionmentioning

confidence: 99%

Arteriovenous Malformation of Tongue: A Case Report and Review of Literature

Pujari

Bahirwani

Balaji

et al. 2011

JIAOMR

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“…Since then a limited number of similar families were published, suggesting autosomal dominant inheritance with variable expression (reviewed in Breugem et al 2001). A hereditary basis underlying the development of solitary CM has not been suggested.…”

Section: Introductionmentioning

confidence: 99%

A locus for hereditary capillary malformations mapped on chromosome 5q

et al. 2002

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Capillary malformations (port-wine stains) are the most common vascular malformations occurring in 0.3% of live births. Most capillary malformations occur sporadically and present as a solitary lesion. Capillary malformations can also occur as a component of well-described syndromes. Familial occurrence of multiple capillary malformations has been described in the literature, suggesting autosomal dominant inheritance with variable expression in this subgroup. A hereditary basis underlying the development of solitary capillary malformations has not been found, but may well be possible. We have mapped a locus for an autosomal dominant disorder in a three-generation family that manifested itself with multiple cutaneous capillary malformations to chromosome 5q13-22. This locus spans 48 cM between the markers D5S647 and D5S659 and harbours several candidate genes. By defining the gene(s) responsible for capillary malformations, we will gain more insight in the pathogenesis of this disorder. It is likely that genes implicated in these familial cases may be involved in the more sporadic cases.

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“…(Burrows et al, 1998 (Mulliken, Glowacki, 1982;Mulliken, Young, 1988;Brevière et al, 1999;Breugem et al, 2001). Síndromes malformativas congênitas são mais associadas às malformações vasculares do que aos hemangiomas (Einchenfield, 1998 Não houve nenhum caso de paciente portador de malformação vascular, mesmo que concomitante à presença do hemangioma.…”

Section: Avaliação Do Contorno Facialunclassified

“…Em termos fisiopatológicos dois processos biológicos devem ser diferenciados para o entendimento das anomalias vasculares: a vasculogênese, processo pelo qual precursores de células endoteliais dão origem a vasos sanguíneos e a angiogênese, processo de desenvolvimento de novos vasos sanguíneos, provenientes da vasculatura já existente (Drolet et al, 1999;Folkman et al, 1997;Breugem et al, 2001 A relação entre o crescimento dos hemangiomas e a ação de hormônios maternos circulantes é também sugerida, podendo explicar de certa forma a maior predileção pelas pacientes do sexo feminino (Boon et al,1996).…”

Section: Aspectos Fisiopatológicosunclassified

“…Podem adquirir dimensões variadas e apresentarem um comportamento bastante agressivo, na dependência do tipo vascular predominante (Mulliken, Young, 1988;Breugem et al, 2001) Nos últimos anos, diferentes subtipos de tumores vasculares têm sido diagnosticados, baseados nos recentes achados de biologia molecular e estudos genéticos (Enjolras et al, 1997;Cattean et al, 1998;Einchenfield, 1998;Drolet et al, 1999,. Enjolras et al, 2001 A incidência dos hemangiomas cutâneos varia de 2.5 a 5 % em recém-nascidos caucasianos.…”

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Estudo crítico dos resultados obtidos no tratamento dos hemangiomas cutâneos cervicofaciais

Goldenberg¹

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Progress toward Understanding Vascular Malformations

Cited by 55 publications

References 137 publications

Arteriovenous Malformation of Tongue: A Case Report and Review of Literature

Arteriovenous Malformation of Tongue: A Case Report and Review of Literature

A locus for hereditary capillary malformations mapped on chromosome 5q

Estudo crítico dos resultados obtidos no tratamento dos hemangiomas cutâneos cervicofaciais

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