Progress toward molecular therapy for diabetes mellitus: A focus on targeting inflammatory factors

Dehghan, Mohadesse; Ghorbani, Fatemeh; Najafi, Sajad; Ravaei, Neda; Karimian, Maede; Kalhor, Kambiz; Movafagh, Abolfazl; Zarch, Seyed Mohsen Aghaei

doi:10.1016/j.diabres.2022.109945

Cited by 20 publications

(14 citation statements)

References 72 publications

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“…They are common in bodily fluids and cellular supernatants. Exosomes transfer their contents, containing proteins, lipids, and RNAs, across cells, and there is mounting indication that they are crucial for intercellular interaction on both a localized and systemic level [ 96 ]. The ability of cell-derived exosomes to get past biological barriers and allow the inserted gene and medicine to access the desired tissue, which has been extremely difficult for synthetic carriers, is of particular importance for regulated pharmaceutical delivery.…”

Section: Mir-122 and Cancer Stem Cellmentioning

confidence: 99%

MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

et al. 2023

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MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological functions, and abnormal miRNA expression has been linked to various illnesses, including cancer. Among the miRNAs, miR-122, miR-206, miR-21, miR-210, miR-223, and miR-424 have been extensively studied in various cancers. Although research in miRNAs has grown considerably over the last decade, much is yet to be discovered, especially regarding their role in cancer therapies. Several kinds of cancer have been linked to dysregulation and abnormal expression of miR-122, indicating that miR-122 may serve as a diagnostic and/or prognostic biomarker for human cancer. Consequently, in this review literature, miR-122 has been analyzed in numerous cancer types to sort out the function of cancer cells miR-122 and enhance patient response to standard therapy.

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Section: Mir-122 and Cancer Stem Cellmentioning

confidence: 99%

MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

et al. 2023

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“…Activated inflammatory pathways [1][2][3] have harmful effects on the structure and function of the enteric nervous system in diabetes [4], which in severe or longer-term cases can even lead to enteric neuropathy [5][6][7]. The details of this complex process have not yet been fully revealed, but it is clear that not only the intercellular processes of the enteric neurons, but also the microenvironment of the enteric ganglia is decisive in the development of diabetic neuropathy.…”

Section: Introductionmentioning

confidence: 99%

Intestinal Region-Dependent Alterations of Toll-Like Receptor 4 Expression in Myenteric Neurons of Type 1 Diabetic Rats

et al. 2023

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Toll-like receptor 4 (TLR4) can activate pro-inflammatory cascades in the gastrointestinal tract. Our aim was to determine TLR4 expression in myenteric neurons of different gut regions using a type 1 diabetic model. Ten weeks after the onset of hyperglycemia, myenteric whole-mount preparations from the duodenum, ileum and colon of streptozotocin-induced diabetic, insulin-treated diabetic and control rats were prepared for TLR4/peripherin double-labelling fluorescent immunohistochemistry. Immunogold electron microscopy was applied to evaluate TLR4 expression in the myenteric perikaryon and neuropil. Tissue TLR4 levels were measured by enzyme-linked immunosorbent assay. In controls, the number and proportion of the TLR4-immunoreactive myenteric neurons showed an increasing tendency to aboral direction. These values were significantly higher in diabetics compared to controls in the duodenum and ileum, but were significantly lower in the colon. In diabetics, the distribution of TLR4-labelling gold particles between the perikaryon and neuropil of myenteric neurons varied in a different way by intestinal segment. TLR4 tissue concentration changed only in the diabetic duodenum, and it decreased in muscle/myenteric plexus-containing homogenates, while it increased in mucosa/submucosa/submucous plexus-containing samples relative to controls. Insulin had beneficial effects on TLR4 expression. These findings support that chronic hyperglycemia has segment-specific effects on TLR4 expression, contributing to gastrointestinal disorders in diabetic patients.

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“…Type 1 diabetes occurs due to the selective destruction of beta cells of the pancreas [ 3 ]. The outcome of this destruction is the decreased production of insulin and its secretion from pancreatic cells [ 4 ]. Both environmental and genetic factors are involved in the pathogenesis of Type 2 DM.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antidiabetic Activity of Oxadiazole Derivative in Rats

Qazi

Ahmad

Sahibzada³

et al. 2023

Evidence-Based Complementary and Alternative Medicine

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The oxadiazole ring has long been used for the treatment of several diseases. This study aimed to analyze the antihyperglycemic and antioxidant roles of the 1,3,4-oxadiazole derivative with its toxicity. Diabetes was induced through intraperitoneal administration of alloxan monohydrate at 150 mg/kg in rats. Glimepiride and acarbose were used as standards. Rats were divided into groups of normal control, disease control, standard, and diabetic rats (treated with 5, 10, and 15 mg/kg of 1,3,4-oxadiazole derivative). After 14 days of oral administration of 1,3,4-oxadiazole derivatives (5, 10, and 15 mg/kg) to the diabetic group, the blood glucose level, body weight, glycated hemoglobin (HbA1c), insulin level, antioxidant effect, and histopathology of the pancreas were performed. The toxicity was measured by estimating liver enzyme, renal function, lipid profile, antioxidative effect, and liver and kidney histopathological study. The blood glucose and body weight were measured before and after treatment. Alloxan significantly increased blood glucose levels, HbA1c, alanine transaminase, aspartate aminotransferase, urea, cholesterol, triglycerides, and creatinine. In contrast, body weight, insulin level, and antioxidant factors were reduced compared to the normal control group. Treatment with oxadiazole derivatives showed a significant reduction in blood glucose levels, HbA1c, alanine transaminase, aspartate aminotransferase, urea, cholesterol, triglycerides, and creatinine as compared to the disease control group. The 1,3,4-oxadiazole derivative significantly improved body weight, insulin level, and antioxidant factors compared to the disease control group. In conclusion, the oxadiazole derivative showed potential antidiabetic activity and indicated its potential as a therapeutic.

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Progress toward molecular therapy for diabetes mellitus: A focus on targeting inflammatory factors

Cited by 20 publications

References 72 publications

MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

Intestinal Region-Dependent Alterations of Toll-Like Receptor 4 Expression in Myenteric Neurons of Type 1 Diabetic Rats

Evaluation of Antidiabetic Activity of Oxadiazole Derivative in Rats

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