Guide to Electroporation and Electrofusion 1992
DOI: 10.1016/b978-0-08-091727-6.50010-1
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Progress toward a Theoretical Model for Electroporation Mechanism: Membrane Electrical Behavior and Molecular Transport

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Cited by 29 publications
(38 citation statements)
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“…This means that in almost all cells that were electroporated the pores created were larger than the size of the molecules of bleomycin [73]. So, experimental results presented here as well as obtained in other studies [154,156] confirm the theoretical conclusions [104,151,160,161] that increasing the amplitude and/or the duration of the electric pulse increases the number and sizes of pores. Usually, to create larger pores, longer pulses are needed [64,73,104,154,156].…”
Section: Electric Treatment Stage: Evolution Of Pore Populationsupporting
confidence: 93%
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“…This means that in almost all cells that were electroporated the pores created were larger than the size of the molecules of bleomycin [73]. So, experimental results presented here as well as obtained in other studies [154,156] confirm the theoretical conclusions [104,151,160,161] that increasing the amplitude and/or the duration of the electric pulse increases the number and sizes of pores. Usually, to create larger pores, longer pulses are needed [64,73,104,154,156].…”
Section: Electric Treatment Stage: Evolution Of Pore Populationsupporting
confidence: 93%
“…12 shows that while electric pulse is on, the pore population evolves by changing both the number and sizes of pores [151,160,161]. For example, modeling studies have revealed that the pulse of nanosecond duration should create smaller pores than the pulse of micro-millisecond duration.…”
Section: Electric Treatment Stage: Evolution Of Pore Populationmentioning
confidence: 98%
“…For example, optical measurements support the idea that some type of rapid membrane structural rearrangement occurs, coincident with membrane conductance changes, which is consistent with pore formation [Neumann et al, 1992]. This is consistent with theoretical models based on physical interactions, in which an increased transmembrane voltage favors entry of water (large dielectric constant) into the membrane (low dielectric constant) [Abidor et al, 1979;Weaver and Mintzer, 1981;Sugar, 1981]. From a purely physical perspective, membrane [Weaver, 1992].…”
Section: Membrane Structural Changes Are Responsible For Electroporationsupporting
confidence: 71%
“…The appearance of pores is believed to involve the stochastic creation of microscopic pores, with contributions from both "kT energy" (stochastic, associated with fundamental thermal fluctuations) and electrical energy (deterministic, associated with the elevated transmembrane voltage) [Abidor et al, 1979;Weaver and Mintzer, 1981;Sugar, 1981]. These "primary" pores are thought to be transient ( Figure 2).…”
Section: E!ectroporation Mechanismmentioning
confidence: 99%
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