Progress on the Synthesis and Applications of Cyanamides

Abstract

Cyanamides are an important class of fine chemicals containing amino and cyano functionalities, which have been widely used for the synthesis of pharmaceuticals, agricultural chemicals, health products and materials, and attracted considerable attention from both organic synthetic chemists and medicinal chemists. Great advances in the synthesis and transformations of cyanamides were made, a diversity of synthetic methods and transformations of cyanamides were developed in the past two decades. In this paper, various synthetic methods and reactions of cyanamides are introduced comprehensively, their characteristics, rules, advantages and disadvantages are also summarized and discussed for the development of new synthetic methods and reactions of cyanamides.

Recent Advances in the Asymmetric Total Synthesis of Camptothecin

“…More recently, Xu and co‐workers described a concise biogenetically inspired formal total synthesis of ( S )‐CPT without employing protecting groups (Scheme 24). [38] The key steps of this process were Pictet‐Spengler reaction, intramolecular oxa‐Diels‐Alder reaction and Winterfeldt biomimetic oxidation. It started with the synthesis of tricyclic intermediate 21 c from tryptamine ( 21 a ) through Pictet‐Spengler reaction and amidation.…”