Progress on the Sulfonylation and Desulfonylative Reactions of Sulfonyl Chlorides

Abstract

Being an active class of electrophiles, the desulfitative cross-couplings of sulfonyl chlorides has emerged as a hot issue nowadays. Under suitable temperature and transitional metal catalysis, sulfonyl chlorides efficiently cross-coupled with a wide range of nucleophiles which were potential in several important organic synthesis. The transitional metal catalyzed desulfitative coupling reactions of sulfonyl chlorides are briefly reviewed and are compared with their corresponding sulfonylation reaction in order to find the key factors that determine desulfonation and further providing reliable proposal for future researches.

Chemoselective Reactions of Functionalized Sulfonyl Halides

“…[3][4][5][6][7][8] On the other hand, sulfonyl chlorides, being classical and well-established reactants, have received less comprehensive coverage. Recent surveys have mentioned them primarily in the context of sulfonamide synthesis, [9][10][11][12] although other reactions [13][14][15][16] and mechanistic aspects [17] have also been discussed.…”