Progress on the Mechanism of Visceral Hypersensitivity in Nonerosive Reflux Disease

Xu, Cao; Niu, Xiaoping

doi:10.1155/2022/4785077

Cited by 8 publications

(5 citation statements)

References 50 publications

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“…We assumed that NERD patients were more concerned or sensitive to dietary and lifestyle triggers than RE patients. Indeed, we also found NERD patients were more likely to coexist with FD, FC, and psychological disorders, indicating the important role of visceral hypersensitivity and psychological factors in the pathogenesis and perception of symptoms of NERD [11,32] as well as reporting more triggers for their reflux symptoms.…”

Section: Discussionmentioning

confidence: 60%

Differences in Dietary and Lifestyle Triggers between Non-Erosive Reflux Disease and Reflux Esophagitis—A Multicenter Cross-Sectional Survey in China

Chen,

Sun,

Fan

et al. 2023

Nutrients

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The occurrence of gastroesophageal reflux disease (GERD) and symptom onset are closely associated with diet. We aimed to compare the dietary and lifestyle triggers between non-erosive reflux disease (NERD) and reflux esophagitis (RE) in Chinese patients and to provide evidence for development of practical dietary modifications for GERD. A multicenter cross-sectional survey was conducted. A total of 396 GERD patients with typical gastroesophageal reflux symptoms who received upper endoscopy in the previous month were enrolled, including 203 cases of NERD patients and 193 cases of RE patients. All participants completed questionnaires including demographic data, reflux symptoms, previous management, dietary and lifestyle habits, triggers of reflux symptoms, psychological status, and quality of life. There were no significant differences in GERD symptom scores between NERD and RE. RE patients had a higher male proportion and smoking/drinking and overeating rates than NERD patients. In the NERD group, more patients reported that fruits, dairy products, yogurt, bean products, cold food, and carbonated beverages sometimes and often induced reflux symptoms and had more triggers compared to RE patients. The number of triggers was positively correlated to GERD symptom score and GERD-HRQL score in both NERD and RE patients. However, 74.0% of GERD patients still often consumed the triggering foods, even those foods that sometimes and often induced their reflux symptoms, which might be related to the reflux relapse after PPI withdrawal considering NERD and RE patients had similar GERD symptom severity. There were some differences in terms of dietary habits, dietary and lifestyle triggers, and related quality of life between NERD and RE, and these results may provide evidence of different approaches toward the dietary modification of NERD and RE patients.

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Section: Discussionmentioning

confidence: 60%

Differences in Dietary and Lifestyle Triggers between Non-Erosive Reflux Disease and Reflux Esophagitis—A Multicenter Cross-Sectional Survey in China

Chen,

Sun,

Fan

et al. 2023

Nutrients

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“…Стоит отметить, что данные о высокой эффективности применения комбинации ИПП и Альфазокса при купировании изжоги неоднократно показаны в исследованиях на популяциях пациентов с НЭРБ [28]. Данный факт, вероятно, свидетельствует о том, что в основе генеза изжоги при НЭРБ и эрозивной форме ГЭРБ могут лежать различные механизмы [29,30].…”

Section: Discussionunclassified

Efficacy of esophagus protection in complex treatment of erosive gastroesophageal reflux disease: a systematic review and meta-analysis of controlled trials

Bordin

Andreev

Маев

2023

Terapevticheskii arkhiv

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Aim. To review the data about the efficacy of esophagus protective agent based on the fixed combination of hyaluronic acid and chondroitin sulfate dissolved in the bioadhesive carrier (poloxamer 407) in the complex therapy of patients with erosive gastroesophageal reflux disease (GERD). Materials and methods. A search in MEDLINE/PubMed, EMBASE, Cochrane, and Russian Science Citation Index of Scientific Electronic Library electronic databases was performed. Relevant original controlled studies of a fixed combination of hyaluronic acid and chondroitin sulfate as an esophagus protective agent in a population of patients with erosive GERD were included. Results. The final analysis included three studies that enrolled 181 patients with erosive GERD. All the studies had a uniform design with the assessment of the primary endpoints (complete epithelialization of esophageal erosions and complete resolution of heartburn) 28 days after the start of therapy. Meta-analysis of the three controlled trials has demonstrated that combination therapy with proton pump inhibitors (PPIs) and esophagus protective agents is significantly more effective than PPI monotherapy for complete epithelialization of esophageal erosions at 28 days of treatment (relative risk 1.267, 95% confidence interval 1.0821.483, p=0.003; I2=21.19%), but did not differ for complete resolution of heartburn on the day 28 of treatment (relative risk 1.638, 95% confidence interval 0.6604.067, p=0.287; I2=92.59%). Conclusion. Combined therapy with PPI and Alfasoxx is significantly more effective than PPI monotherapy for the epithelialization of esophageal erosions in patients with erosive GERD.

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“…VH contributes to acid reflux and heartburn symptoms in NERD patients. Treatments using TRPV1 antagonists, tricyclic antidepressants, and other drugs have shown good results in managing NERD [ 171 ]. Among various oral delivery approaches, CSNPs are promising vehicles with the potential to enhance oral drug retention and controlled absorption.…”

Section: Chitosan-based Nanoparticle-based Systems For Gerd Treatmentmentioning

confidence: 99%

Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment

Herdiana

2023

Polymers

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Gastroesophageal Reflux Disease (GERD) is a chronic ailment that results from the backward flow of stomach acid into the esophagus, causing heartburn and acid regurgitation. This review explores nanotechnology as a novel treatment approach for GERD. Chitosan nanoparticles (CSNPs) offer several advantages, including biocompatibility, biodegradability, and targeted drug delivery capabilities. CSNPs have been extensively studied due to their ability to encapsulate and release medications in a controlled manner. Different nanoparticle (NP) delivery systems, including gels, microspheres, and coatings, have been developed to enhance drug retention, drug targeting, and controlled release in the esophagus. These nanoparticles can target specific molecular pathways associated with acid regulation, esophageal tissue protection, and inflammation modulation. However, the optimization of nanoparticle formulations faces challenges, including ensuring stability, scalability, and regulatory compliance. The future may see CSNPs combined with other treatments like proton pump inhibitors (PPIs) or mucosal protectants for a synergistic therapeutic approach. Thus, CSNPs provide exciting opportunities for novel GERD treatment strategies.

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Progress on the Mechanism of Visceral Hypersensitivity in Nonerosive Reflux Disease

Cited by 8 publications

References 50 publications

Differences in Dietary and Lifestyle Triggers between Non-Erosive Reflux Disease and Reflux Esophagitis—A Multicenter Cross-Sectional Survey in China

Differences in Dietary and Lifestyle Triggers between Non-Erosive Reflux Disease and Reflux Esophagitis—A Multicenter Cross-Sectional Survey in China

Efficacy of esophagus protection in complex treatment of erosive gastroesophageal reflux disease: a systematic review and meta-analysis of controlled trials

Chitosan Nanoparticles for Gastroesophageal Reflux Disease Treatment

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