Progress on Terpenoids With Biological Activities Produced by Plant Endophytic Fungi in China Between 2017 and 2019

Abstract

Plant endophytic fungi are an important part of plant microecosystems and a natural resource for human survival and development. Various bioactive natural products produced by plant endophytic fungi show promising prospects in biopharmacy, agricultural production, and industrial fermentation. Terpenoids, the most numerous and structurally diverse natural products from endophytic fungi, possess a broad range of biological activities and huge potential for drug development. It is critically significant for ecological and economic benefits to develop their activities. This paper utilized literature analysis to summarize 200 terpenoids with biological activities that are derived from plant endophytic fungi in China between 2017 and 2019. Among them, sesquiterpenoids were the most important kind of terpenoids, and Trichoderma and Aspergillus species were main terpenoid-producing plant endophytic fungi. Furthermore, these terpenoids displayed multifarious biological activities, including antimicrobial, antipathogenic, and anti-inflammatory activities, as well as cytotoxicity, antitumor agents, and enzyme inhibition.

Chemical analysis and anticancer activity of sesterterpenoid from an endophytic fungus Hypomontagnella monticulosa Zg15SU and its host Zingiber griffithii Baker

“…2011 ). Majority of sesterterpenoids produced by fungi were reported as ophiobolin-type derivatives in the Chinese region dominantly produced by Aspergillus and Bipolaris which also showed diverse biological activities ( Zhao et al. 2020 ).…”

“…Endophytic fungi produce various forms of terpenoids, but mainly the sesquiterpenoids which displayed multifarous biological activities, such as anticancers, antimicrobials, antitumors, and enzyme inhibitions (de Souza et al 2011). Majority of sesterterpenoids produced by fungi were reported as ophiobolin-type derivatives in the Chinese region dominantly produced by Aspergillus and Bipolaris which also showed diverse biological activities (Zhao et al 2020). Asperophioboloins A-K were isolated from a mangrove fungus, Aspergillus sp.…”

A New Quinazolinone Alkaloid from Rhodiola tibetica Endophytic Fungus Penicillium sp. HJT-A-6

“…Endophytic fungi can both independently produce various structural types of secondary metabolites and participate in the biosynthesis or biotransformation of secondary metabolites in host plants, making them an important source of active natural products. Active natural products derived from endophytic fungi hold vast potential applications in biopharmaceuticals, agricultural production, and industrial fermentation [2,[8][9][10].…”

Diterpenes Specially Produced by Fungi: Structures, Biological Activities, and Biosynthesis (2010–2020)

“…Consequently, a wealth of novel skeletons, biosynthetic pathways, and bioactivities have provided new opportunities for drug discovery, genome mining, enzymology, and chemical synthesis. During the period covered in this review, there have been several more specialized reviews of fungal metabolites [ 26 , 27 , 28 ], including benzene carbaldehydes [ 29 ], trichothecenes [ 30 , 31 ], protoilludane sesquiterpenoids [ 32 ], meroterpenoids [ 33 , 34 , 35 ], meroterpenoid cyclases [ 36 ], terpenoids [ 37 ], and natural product biosynthetic genes and enzymes of fungi [ 17 , 18 , 38 , 39 ]. In addition, the isolation and chemistry of diterpenoids from terrestrial sources have been summarized [ 40 ].…”