Progress of Research in Cell‐in‐Cell Phenomena

Yang, Youshan; Li, Jicheng

doi:10.1002/ar.21537

Cited by 40 publications

(38 citation statements)

References 29 publications

(41 reference statements)

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“…A similar phenomenon is observed among epithelial cells in human cancer (Brouwer et al, 1984; Overholtzer et al, 2007; Overholtzer and Brugge, 2008; Sharma and Dey, 2011; Yang and Li, 2012; Cano et al, 2012), suggesting this primeval process may promote survival within the tumour microenvironment (Fais, 2007; Matarrese et al, 2008; He et al, 2013; Lozupone and Fais, 2015). Homotypic epithelial cell cannibalism can occur by entosis, an intriguing process through which one live and viable cell is completely engulfed by another, yielding a ‘cell-in-cell’ structure (Overholtzer et al, 2007).…”

Section: Introductionsupporting

confidence: 68%

Mitosis can drive cell cannibalism through entosis

Durgan

Tseng

Hamann

et al. 2017

eLife

105

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Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in human epithelial cells, driven by mitosis. Mitotic entosis is regulated by Cdc42, which controls mitotic morphology. Cdc42 depletion enhances mitotic deadhesion and rounding, and these biophysical changes, which depend on RhoA activation and are phenocopied by Rap1 inhibition, permit subsequent entosis. Mitotic entosis occurs constitutively in some human cancer cell lines and mitotic index correlates with cell cannibalism in primary human breast tumours. Adherent, wild-type cells can act efficiently as entotic hosts, suggesting that normal epithelia may engulf and kill aberrantly dividing neighbours. Finally, we report that Paclitaxel/taxol promotes mitotic rounding and subsequent entosis, revealing an unconventional activity of this drug. Together, our data uncover an intriguing link between cell division and cannibalism, of significance to both cancer and chemotherapy.DOI: http://dx.doi.org/10.7554/eLife.27134.001

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Section: Introductionsupporting

confidence: 68%

Mitosis can drive cell cannibalism through entosis

Durgan

Tseng

Hamann

et al. 2017

eLife

105

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“…There are many fates for the internalized cells during entosis, such as undergoing the lysosome-mediated degradation process or undergoing cell division within the host cells 116, 120 . Entosis could also disturb the host cell cytokinesis resulting in aneuploidy and could be regarded as a non-genetic route to aneuploidy in human cancers 121, 122 .…”

Section: Differential Ar Roles In 5 Types Of Pca Cell Deathmentioning

confidence: 99%

“…Entosis could also disturb the host cell cytokinesis resulting in aneuploidy and could be regarded as a non-genetic route to aneuploidy in human cancers 121, 122 . Overall, as the main outcome of entosis is the death of the internalized cells, it might represent a novel pathway to eliminate detached cancer cells, and thus its stimulation may offer a better outcome in clinical oncology 116, 120 .…”

Section: Differential Ar Roles In 5 Types Of Pca Cell Deathmentioning

confidence: 99%

Androgen receptor (AR) positive vs negative roles in prostate cancer cell deaths including apoptosis, anoikis, entosis, necrosis and autophagic cell death

Wen

Niu

Lee

et al. 2014

Cancer Treatment Reviews

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Androgen/androgen receptor (AR) signaling plays pivotal roles in the prostate development and homeostasis as well as in the progression of prostate cancer (PCa). Androgen deprivation therapy (ADT) with anti-androgens remains as the main treatment of PCa, and it has been shown to effectively suppress PCa growth during the first 12–24 months. However, ADT eventually fails and tumors may re-grow and progress into the castration resistant stage. Recent reports revealed that AR might play complicated and even opposite roles in PCa progression that might depend on cell types and tumor stages. Importantly, AR may influence PCa progression via differential modulation of various cell deaths including apoptosis, anoikis, entosis, necrosis, and autophagic cell deaths. Targeting AR may induce PCa cell apoptosis, autophagic cell deaths and programmed necrosis, yet targeting AR may also suppress cell deaths via anoikis and entosis that may potentially lead to increased metastasis. These differential functions of AR in various types of PCa cell death might challenge the current ADT with anti-androgens treatment. Further detailed dissection of molecular mechanisms by which AR modulates different PCa cell deaths will help us to develop a better therapy to battle PCa.

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“…Since its first report a century ago, diverse forms of CICs have been described, including entosis, heterotypic cell cannibalism, emperitosis, homotypic cell cannibalism and phagocytosis and the like emperipolesis [4, 17, 13, 32, 33]. The pathway of the first two cell-in-cell deaths is lysosome-dependent cell death [6, 7], and the third one, which is elucidated and termed by us, is a typical caspase-dependent cell death [1, 8, 13].…”

Section: Cell-in-cell Phenomenon Is Diverse and Evolutionarily Conservedmentioning

confidence: 99%

“…The three carefully studied types of cell-in-cell death are characterized very similarly through cell entrance and intracellular deaths of effector cells. However, after a closer look, the distinctions are clear [17]. We and Fais et al .…”

Section: Future Efforts On Cell-in-cell Researchmentioning

confidence: 99%

Cell-in-cell phenomenon: A New Paradigm in Life Sciences.

Wang

2015

CMM

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Cell-in-cell, a phenomenon characterized by one or more viable cells entering actively into another cell, was observed more than a century and has only attracted more attention in recent years and is becoming a new hot topic in the biological field, owing its biological significance in evolutionary as well as physiological and pathological relevance in development, homeostasis and diseases. In this paper we focus on the diversity, evolutionary conservatism and clinical implication of cell-in-cell as well as latest opinions on the research strategies. Based on the findings from our laboratory and other research groups three working models of cell-in-cell are also proposed.

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Progress of Research in Cell‐in‐Cell Phenomena

Cited by 40 publications

References 29 publications

Mitosis can drive cell cannibalism through entosis

Mitosis can drive cell cannibalism through entosis

Androgen receptor (AR) positive vs negative roles in prostate cancer cell deaths including apoptosis, anoikis, entosis, necrosis and autophagic cell death

Cell-in-cell phenomenon: A New Paradigm in Life Sciences.

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