Progress of photodynamic therapy applications in the treatment of musculoskeletal sarcoma (Review)

Zhang, Xianghong; Liu, Tang; Li, Zhihong; Zhang, Xiangsheng

doi:10.3892/ol.2014.2332

Cited by 29 publications

(19 citation statements)

References 53 publications

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“…Finally, in addition to eliciting direct cytotoxicity, PDT provokes a variety of additional beneficial anti‐tumor effects such as an acute inflammatory response, anti‐vascular effects and an activation of the immune system . PDT has commonly been used for the treatment of solid tumors at superficial anatomical locations, however, its application in other tumors at more inaccessible sites has become an aim of clinical investigations . Additionally to the advantage of PDT as a local application, also a systemic immune response against tumors have been reported, therefore PDT is potentially not only effective against local tumor growth but also against distant metastases.…”

mentioning

confidence: 99%

Foscan and foslip based photodynamic therapy in osteosarcoma in vitro and in intratibial mouse models

Meier

Botter

Campanile

et al. 2017

Intl Journal of Cancer

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Current osteosarcoma therapies cause severe treatment-related side effects and chemoresistance, and have low success rates. Consequently, alternative treatment options are urgently needed. Photodynamic therapy (PDT) is a minimally invasive, local therapy with proven clinical efficacy for a variety of tumor types. PDT is cytotoxic, provokes anti-vascular effects and stimulates tumor cell targeting mechanisms of the immune system and, consequently, has potential as a novel therapy for osteosarcoma patients. This study investigated the uptake and the dark- and phototoxicity and cytotoxic mechanisms of the photosensitizer (PS) 5,10,15,20-tetrakis(meta-hydroxyphenyl) chlorine (mTHPC, Foscan) and a liposomal mTHPC formulation (Foslip) in the human 143B and a mouse K7M2-derived osteosaroma cell line (K7M2L2) in vitro. Second, the tumor- and metastasis-suppressive efficacies of mTHPC formulations based PDT and associated mechanisms in intratibial, metastasizing osteosarcoma mouse models (143B/SCID and syngeneic K7M2L2/BALB/c) were studied. The uptake of Foscan and Foslip in vitro was time- and dose-dependent and resulted in mTHPC and light dose-dependent phototoxicity associated with apoptosis. In vivo, the uptake of both i.v. administered mTHPC formulations was higher in tumor than in healthy control tissue. PDT caused significant (Foscan p < 0.05, Foslip p < 0.001) tumor growth inhibition in both models. A significant (Foscan p < 0.001, Foslip p < 0.001) immune system-dependent suppression of lung metastasis was only observed in the K7M2L2/BALB/c model and was associated with a marked infiltration of T-lymphocytes at the primary tumor site. In conclusion, mTHPC-based PDT is effective in clinically relevant experimental osteosarcoma and suppresses lung metastasis in immunocompetent mice with beneficial effects of the liposomal mTHPC formulation Foslip.

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mentioning

confidence: 99%

Foscan and foslip based photodynamic therapy in osteosarcoma in vitro and in intratibial mouse models

Meier

Botter

Campanile

et al. 2017

Intl Journal of Cancer

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“…PDT induces tumor destruction by cellular effects, vascular effects or both. Cellular lethal effect may be caused by an imbalance in the mitochondria, lysosomes, plasma, hydrolytic enzymes, certain cytokines and calcium, or even by DNA damage [91]. As a result, the tumor cells are eliminated through apoptotic pathway or necrosis.…”

Section: Biophysical Therapies In Oncologymentioning

confidence: 99%

Adjuvant Biophysical Therapies in Osteosarcoma

Carina

Costa

Sartori

et al. 2019

Cancers

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Osteosarcoma (OS) is a primary bone sarcoma, manifesting as osteogenesis by malignant cells. Nowadays, patients’ quality of life has been improved, however continuing high rates of limb amputation, pulmonary metastasis and drug toxicity, remain unresolved issues. Thus, effective osteosarcoma therapies are still required. Recently, the potentialities of biophysical treatments in osteosarcoma have been evaluated and seem to offer a promising future, thanks in this field as they are less invasive. Several approaches have been investigated such as hyperthermia (HT), high intensity focused ultrasound (HIFU), low intensity pulsed ultrasound (LIPUS) and sono- and photodynamic therapies (SDT, PDT). This review aims to summarize in vitro and in vivo studies and clinical trials employing biophysical stimuli in osteosarcoma treatment. The findings underscore how the technological development of biophysical therapies might represent an adjuvant role and, in some cases, alternative role to the surgery, radio and chemotherapy treatment of OS. Among them, the most promising are HIFU and HT, which are already employed in OS patient treatment, while LIPUS/SDT and PDT seem to be particularly interesting for their low toxicity.

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“… 34 The PDT mediated by 5-ALA has gained great interest in the treatment of various tumors, such as brain, lung, esophageal, gastrointestinal, bladder, prostate, head and neck, oral, and skin cancers. 35 Apart from its selectivity per se, nanoparticle-based approaches and active targeting methods can further enhance the selective accumulation of PpIX in cancer tissues. 36 , 37 The fluorescence signal emitted by PpIX can be detected and used to discriminate cancer tissues from normal tissues.…”

Section: Intraoperative Fluorescence Imagingmentioning

confidence: 99%

Combination of Fluorescence-Guided Surgery With Photodynamic Therapy for the Treatment of Cancer

et al. 2017

Mol Imaging

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Specific visualization of body parts is needed during surgery. Fluorescence-guided surgery (FGS) uses a fluorescence contrast agent for in vivo tumor imaging to detect and identify both malignant and normal tissues. There are several advantages and clinical benefits of FGS over other conventional medical imaging modalities, such as its safety, effectiveness, and suitability for real-time imaging in the operating room. Recent advancements in contrast agents and intraoperative fluorescence imaging devices have led to a greater potential for intraoperative fluorescence imaging in clinical applications. Photodynamic therapy (PDT) is an alternative modality to treat tumors, which uses a light-sensitive drug (photosensitizers) and special light to destroy the targeted tissues. In this review, we discuss the fluorescent contrast agents, some newly developed imaging devices, and the successful clinical application of FGS. Additionally, we present the combined strategy of FGS with PDT to further improve the therapeutic effect for patients with cancer. Taken together, this review provides a unique perspective and summarization of FGS.

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Progress of photodynamic therapy applications in the treatment of musculoskeletal sarcoma (Review)

Cited by 29 publications

References 53 publications

Foscan and foslip based photodynamic therapy in osteosarcoma in vitro and in intratibial mouse models

Foscan and foslip based photodynamic therapy in osteosarcoma in vitro and in intratibial mouse models

Adjuvant Biophysical Therapies in Osteosarcoma

Combination of Fluorescence-Guided Surgery With Photodynamic Therapy for the Treatment of Cancer

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