Progress of nerve bridges in the treatment of peripheral nerve disruptions

Abstract

Clinical repair of a nerve defect is one of the most challenging surgical problems. Autologous nerve grafting remains the gold standard treatment in addressing peripheral nerve injuries that cannot be bridged by direct epineural suturing. However, the autologous nerve graft is not readily available, and the process of harvesting autologous nerve graft results in several complications. Thus, it is necessary to explore an alternative to autologous nerve graft. In the last few decades, with significant advances in the life sciences and biotechnology, a lot of artificial nerve grafts have been developed to aim at the treatment of peripheral nerve disruptions. Artificial nerve grafts range from biological tubes to synthetic tubes and from nondegradable tubes to degradable tubes. Among them, acellular nerve allografts and artificial nerve repair conduits are two kinds of the most promising substitutes for nerve autografts. The history, research status, and prospect of acellular nerve allografts and artificial nerve repair conduits are described briefly in this review.

Microstructure, thermal and rheological properties of poly(L‐lactide‐co‐ε‐caprolactone) tapered block copolymer for potential use in biomedical applications

“…If the nerve guide breaks down at an early stage, fibrous tissue forms inside the tube and impairs further maturation of the regenerated nerve. Moreover, too rapid degradation may cause the regenerated axons to suffer mechanical or biochemical damage 33 . Several biodegradable synthetic materials have been demonstrated to support nerve regeneration.…”

“…Moreover, too rapid degradation may cause the regenerated axons to suffer mechanical or biochemical damage. 33 Several biodegradable synthetic materials have been demonstrated to support nerve regeneration.…”