Progress of molecular imprinting technique for enantioseparation of chiral drugs in recent ten years

Pu, Junli; Wang, Hongwei; Huang, Chao; Bo, Chunmiao; Gong, Bolin; Ou, Junjie

doi:10.1016/j.chroma.2022.462914

Cited by 34 publications

(22 citation statements)

References 103 publications

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“…Several other materials, including MIPs, , hollow fibers, and the composite of multiple materials, − were also applied for chiral membrane separation. The chiral membrane separation has been rapidly improved in its scale as well as purity toward large-scale industrial use.…”

Section: Membrane Separationmentioning

confidence: 99%

Recent Advances in Separation and Analysis of Chiral Compounds

Yan

2023

Anal. Chem.

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Section: Membrane Separationmentioning

confidence: 99%

Recent Advances in Separation and Analysis of Chiral Compounds

Yan

2023

Anal. Chem.

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“…The principle is that the monomer and the crosslinking agent are copolymerized, and the target molecule is used as a template molecule to combine with the monomer functional group to form a site. When the template molecule is removed, a cavity is formed, and the target molecule is selectively recognized (as shown in Figure 5) (Hermawan et al, 2020;Shen et al, 2021;Pu et al, 2022). A molecularly imprinted polymer (MIP) is synthesized by MIT, and it is used in the separation and detection by integral column chromatography to improve the specific recognition function of the target molecule.…”

Section: Chromatographic Detection Technology 31 Molecular Imprinting...mentioning

confidence: 99%

“…FIGURE 5Schematic diagram of molecular imprinting technique. Reprinted with permission from Ref (Pu et al, 2022)…”

mentioning

confidence: 99%

Functionalized monolithic columns: Recent advancements and their applications for high-efficiency separation and enrichment in food and medicine

Wang

Guo

et al. 2022

Front. Chem.

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The chromatographic column is the core of a high-performance liquid chromatography (HPLC) system, and must have excellent separation efficiency and selectivity. Therefore, functional modification materials for monolithic columns have been rapidly developed. This study is a systematic review of the recently reported functionalized monolithic columns. In particular, the study reviews the types of functional monomers under different modification conditions, as well as the separation and detection techniques combined with chromatography, and their development prospects. In addition, the applications of functionalized monolithic columns in food analysis, biomedicine, and the analysis of active ingredient of Chinese herbal medicines in recent years are also discussed. Also reviewed are the functionalized monolithic columns for qualitative and quantitative analysis. It provided a reference for further development and application of organic polymer monolithic columns.

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“…They are obtained by using template molecules polymerized with functional monomers and cross-linkers. After the template molecules are removed, cavities matching the spatial configuration of the template molecules are formed to achieve highly selective recognition of target substances in complex samples [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Deep-Eutectic-Solvent-Based Mesoporous Molecularly Imprinted Polymers for Purification of Gallic Acid from Camellia spp. Fruit Shells

Shen

Yan

et al. 2022

IJMS

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To produce antioxidant substances from agricultural waste Camellia spp. fruit shells before their further utilization, gallic acid from five kinds of Camellia spp. fruit shells was separated on specific recognition by deep eutectic solvent molecularly imprinted polymers (DES@MIPs), which were prepared by bulk polymerization using gallic acid as the template and deep eutectic solvents (α-methylacrylic acid and choline chloride) as functional monomers. The optimized DES@MIPs were characterized by scanning electron microscopy, particle size analysis, nitrogen sorption porosimetry, elemental analysis, Fourier transform infrared spectroscopy, and thermal gravimetric analysis. The adsorptive behavior of gallic acid on DES@MIPs was also investigated. The results indicated that DES@MIPs were successfully prepared as mesoporous materials with average pore diameter of 9.65 nm and total pore volume of 0.315 cm3 g−1, and the adsorption behavior was multilayer adsorption and pseudo-second-order kinetics with the saturation adsorptive capacity of gallic acid reaching 0.7110 mmol g−1. Although the content of gallic acid in five fruit shells was quite different, the purification recovery of gallic acid was high, ranging from 87.85–96.75% with a purity over 80%. Thus, the purification of gallic acid from Camellia spp. fruit shells could be realized feasibly using DES@MIPs with favorable economic and environmental benefits.

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Progress of molecular imprinting technique for enantioseparation of chiral drugs in recent ten years

Cited by 34 publications

References 103 publications

Recent Advances in Separation and Analysis of Chiral Compounds

Recent Advances in Separation and Analysis of Chiral Compounds

Functionalized monolithic columns: Recent advancements and their applications for high-efficiency separation and enrichment in food and medicine

Deep-Eutectic-Solvent-Based Mesoporous Molecularly Imprinted Polymers for Purification of Gallic Acid from Camellia spp. Fruit Shells

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