Progress of Flexible Electronics in Neural Interfacing – A Self‐Adaptive Non‐Invasive Neural Ribbon Electrode for Small Nerves Recording

Xiang, Zhuolin; Yen, Shih Cheng; Sheshadri, Swathi; Wang, Jiahui; Lee, Sanghoon; Liu, Yu Hang; Liao, Lun-De; Thakor, Nitish V.; Lee, Chengkuo

doi:10.1002/adma.201503423

Cited by 99 publications

(92 citation statements)

References 47 publications

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“…Additionally, manual oversight was implemented to identify and remove myographic signals that were included in the threshold range. EMGs have a larger crest-to-crest period of > 2 ms compared to CAPs, as well as larger amplitudes (Lee et al 2017;Xiang, Sheshadri, et al 2016;Xiang, Yen, et al 2016).…”

Section: Discussionmentioning

confidence: 99%

A wrappable microwire electrode for awake, chronic interfacing with small diameter autonomic peripheral nerves

Goldman

et al. 2018

Preprint

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Bioelectronic medicine requires the ability to monitor and modulate nerve activity in awake patients over time. The vagus nerve is a promising stimulation target, and preclinical models often use mice. However, an awake, chronic mouse vagus nerve interface has yet to be demonstrated. Here, we developed a functional wrappable microwire electrode to chronically interface with the small diameter mouse cervical vagus nerve (~100 μ m). In an acute setting, the wrappable microwire had similar recording performance to commercially available electrodes. A chronic, awake mouse model was then developed to record spontaneous compound action potentials (CAPs). Viable signal-to-noise ratios (SNRs) were obtained from the wrappable microwires between 30 and 60 days (n = 8). Weekly impedance measurements showed no correlation between SNR or time. The wrappable microwires successfully interfaced with small diameter nerves and has been validated in a chronic, awake preclinical model, which can better facilitate clinical translation for bioelectronic medicine.

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Section: Discussionmentioning

confidence: 99%

A wrappable microwire electrode for awake, chronic interfacing with small diameter autonomic peripheral nerves

Goldman

et al. 2018

Preprint

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“…glucose, pH level and other diagnostic markers), skin treatments in cosmetics and bioelectric treatments (electroceuticals) [14–21]. While flexible and stretchable patches with polymer microneedles have been reported [22–27], to the best of our knowledge flexible and stretchable patches in combination with sharp and stiff stainless steel microneedle arrays have not been demonstrated to date. A large number of studies on microneedle geometries, materials and fabrication methods have been reported [18].…”

Section: Introductionmentioning

confidence: 99%

Flexible and Stretchable Microneedle Patches with Integrated Rigid Stainless Steel Microneedles for Transdermal Biointerfacing

et al. 2016

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This paper demonstrates flexible and stretchable microneedle patches that combine soft and flexible base substrates with hard and sharp stainless steel microneedles. An elastomeric polymer base enables conformal contact between the microneedle patch and the complex topography and texture of the underlying skin, while robust and sharp stainless steel microneedles reliably pierce the outer layers of the skin. The flexible microneedle patches have been realized by magnetically assembling short stainless steel microneedles into a flexible polymer supporting base. In our experimental investigation, the microneedle patches were applied to human skin and an excellent adaptation of the patch to the wrinkles and deformations of the skin was verified, while at the same time the microneedles reliably penetrate the surface of the skin. The unobtrusive flexible and stretchable microneedle patches have great potential for transdermal biointerfacing in a variety of emerging applications such as transdermal drug delivery, bioelectric treatments and wearable bio-electronics for health and fitness monitoring.

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“…Histological inspection showed the nanoclip implant provokes a typical fibrotic response, completely Interestingly, we found limited fibrotic penetration between the nerve and nanoclip up to 11 months after implant (Figure 2c), suggesting the potential for long-term viability of the preparation (Caravaca et al, 2017;Hiebl et al, 2010;Xiang et al, 2016;Xue et al, 2015).…”

Section: Uncompromised Nerve Function Following Implantmentioning

confidence: 71%

Printable microscale interfaces for long-term peripheral nerve mapping and precision control

Otchy

Michas

Lee

et al. 2019

Preprint

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The nascent field of bioelectronic medicine seeks to decode and modulate peripheral nervous system signals to obtain therapeutic control of targeted end organs and effectors. Current approaches rely heavily on electrodebased devices, but size scalability, material and microfabrication challenges, limited surgical accessibility, and the biomechanically dynamic implantation environment are significant impediments to developing and deploying advanced peripheral interfacing technologies. Here, we present a microscale implantable device -the nanoclipfor chronic interfacing with fine peripheral nerves in small animal models that begins to meet these constraints.We demonstrate the capability to make stable, high-resolution recordings of behaviorally-linked nerve activity over multi-week timescales. In addition, we show that multi-channel, current-steering-based stimulation can achieve a high degree of functionally-relevant modulatory specificity within the small scale of the device. These results highlight the potential of new microscale design and fabrication techniques for the realization of viable implantable devices for long-term peripheral interfacing.

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Progress of Flexible Electronics in Neural Interfacing – A Self‐Adaptive Non‐Invasive Neural Ribbon Electrode for Small Nerves Recording

Cited by 99 publications

References 47 publications

A wrappable microwire electrode for awake, chronic interfacing with small diameter autonomic peripheral nerves

A wrappable microwire electrode for awake, chronic interfacing with small diameter autonomic peripheral nerves

Flexible and Stretchable Microneedle Patches with Integrated Rigid Stainless Steel Microneedles for Transdermal Biointerfacing

Printable microscale interfaces for long-term peripheral nerve mapping and precision control

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