Progress of Animal Research on Electro-acupuncture Treatment for Depression

Mo, Yuping; Yao, Haiqiang; Song, Hongtao; Xu, Anping; Tang, Yinshan; Li, Zhigang

doi:10.1016/s1001-9294(14)60023-7

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…Furthermore, since animals likely do not understand the difference between true vs sham therapies, we can infer that they are not likely to exhibit a placebo response. [71][72][73][74][75][76][77][78][79][80][81] Some argue that acupuncture is no better than placebo since a few human studies showed no significant difference between sham needling and true acupuncture-ignoring the effects of needle insertion itself. 82 Nevertheless, blinding attempts with non-penetrating shams are possible in humans.…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Complementary and alternative medicine therapies for the anesthesiologist and pain practitioner: a narrative review

Woodbury

Soong

Fishman

et al. 2015

Can J Anesth/J Can Anesth

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Section: Mechanisms Of Actionmentioning

confidence: 99%

Complementary and alternative medicine therapies for the anesthesiologist and pain practitioner: a narrative review

Woodbury

Soong

Fishman

et al. 2015

Can J Anesth/J Can Anesth

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The effects and mechanisms of modified Xiaoyaosan on chronic unpredictable mild stress (CUMS)-induced depressive mice based on network pharmacology

Liu,

Guo,

et al. 2024

Journal of Ethnopharmacology

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The mechanism of electroacupuncture for depression on basic research: a systematic review

et al. 2021

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Background Electroacupuncture (EA) is generally accepted as a safe and harmless treatment option for alleviating depression. However, there are several challenges related to the use of EA. Although EA has been shown to be effective in treating depression, the molecular mechanism is unclear. Objective To reveal the therapeutic effect of EA and its possible mechanism in the treatment of depression. Search strategy We performed a systematic search according to PRISMA guidelines. We electronically searched PubMed, Web of Science (WOS), the China National Knowledge Infrastructure (CNKI), Wanfang Data Information Site and the VIP information database for animal studies in English published from the inception of these databases to December 31, 2019. Inclusion criteria Electronic searches of PubMed, WOS, the CNKI, Wanfang and the VIP database were conducted using the following search terms: (depression OR depressive disorder OR antidepressive), (rat OR mouse) AND (acupuncture OR EA). Data extraction and analysis The data were extracted primarily by one author, and a follow-up review was conducted by the other authors. Results Twenty-eight articles met the inclusion criteria. The most commonly used method for inducing depression in animal models was 21 days of chronic unpredictable mild stress. For the depression model, the most commonly selected EA frequency was 2 Hz. Among the 28 selected studies, 11 studies observed depression-related behaviors and used them as indicators of EA efficacy. The other 17 studies focused on mechanisms and assessed the indexes that exhibited abnormalities that were known to result from depression and then returned to a normal range after EA treatment. Treatment of depression by EA involves multiple therapeutic mechanisms, including inhibition of HPA axis hyperactivity and inflammation, regulation of neuropeptides and neurotransmitters, modulation of the expression of particular genes, restoration of hippocampal synaptic plasticity, increased expression of BDNF, and regulation of several signaling pathways. Conclusions This review reveals that the mechanisms underlying the effect of acupuncture involve multiple pathways and targets, suggesting that acupuncture is a wholistic treatment for people rather than for diseases. Our findings also explain why acupuncture can treat various disorders in addition to depression.

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Progress of Animal Research on Electro-acupuncture Treatment for Depression

Cited by 4 publications

References 3 publications

Complementary and alternative medicine therapies for the anesthesiologist and pain practitioner: a narrative review

Complementary and alternative medicine therapies for the anesthesiologist and pain practitioner: a narrative review

The effects and mechanisms of modified Xiaoyaosan on chronic unpredictable mild stress (CUMS)-induced depressive mice based on network pharmacology

The mechanism of electroacupuncture for depression on basic research: a systematic review

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