Progress in the Treatment of Small Intestine Cancer

Symons, Rebecca; Daly, Daniel; Gandy, Robert C.; Goldstein, David; Aghmesheh, Morteza

doi:10.1007/s11864-023-01058-3

Cited by 7 publications

(4 citation statements)

References 88 publications

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“…Malignant tumor of small intestine is very rare, accounting for approximately 3% of all gastrointestinal malignancies. The most common histological subtypes include adenocarcinomas, neuroendocrine tumors (NETs) and gastrointestinal mesenchymal stromal tumors (GISTs), whereas ASC originating in the duodenum is very rare [10]. Up to now, only very few cases have been published in English literature.…”

Section: Discussionmentioning

confidence: 99%

Primary adenosquamous carcinoma of the duodenum: a rare case report with review of literature

Zhang,

Song,

et al. 2023

Preprint

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Adenosquamous carcinoma of the duodenum is a malignant tumor consisting of adenocarcinoma and components of squamous cell carcinoma, which is extremely rare. There are very few available case reports, and its clinicopathological features and treatment strategies remain difficult to elucidate. We describe a patient diagnosed with adenosquamous carcinoma of the duodenum and perform a literature review of reported cases. A 55-year-old male patient presented with a history of jaundice and fever with pruritus and clay-colored stools. Preoperative investigations suggested an elevation of transaminase, bilirubin, and tumor markers. Enhanced MRI of the abdomen suggested a mass in the descending portion of duodenum and a mass was visible in the pancreatic region, with no distant metastases. Endoscopy of the upper gastrointestinal tract revealed an infiltrative growth mass invading the duodenal papilla in the descending part of the duodenum. The patient underwent Whipple procedure. Histopathological and immunohistochemical examination confirmed adenosquamous carcinoma of the duodenum. Although R0 resection was performed, the cancer developed hepatic metastases 2 months after surgery and the patient died 4 months after surgery.

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Section: Discussionmentioning

confidence: 99%

Primary adenosquamous carcinoma of the duodenum: a rare case report with review of literature

Zhang,

Song,

et al. 2023

Preprint

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“…15 In advanced disease, nonprescription of chemotherapy was also associated with reduced survival time. 17 Currently, surgical resection with lymph node dissection is the standard of therapy for localized and resectable disease, 18 although endoscopic resection may be appropriate for in situ disease or T1 disease when surgical management is precluded. The role of adjuvant therapy is controversial, with some studies reporting a survival benefit and others claiming the treatment outcome is insufficient.…”

Section: Discussionmentioning

confidence: 99%

Small Intestinal Adenocarcinoma Involving a Submucosal Ectopic Lymph Node: A Case Report

Hein,

Singh,

Cohen

2023

Int J Surg Pathol

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An 83-year-old male with a 55-year history of Crohn's disease, ileocecectomy 40 years prior, and naturopathic treatment for 25 years, presented with nausea, vomiting, and abdominal pain. Computed tomography of abdomen and pelvis demonstrated partial small intestinal obstruction and a 4.4-cm solid left renal mass. After 3 months of recurrent intestinal obstruction and development of a pericolonic abscess, resection of the ileocolonic anastomosis, abscess, and partial nephrectomy were performed. Histopathology demonstrated chronic active enteritis with fistula tract formation, consistent with Crohn's disease, and moderately differentiated small intestinal adenocarcinoma extending from mucosa into subserosa. A submucosal intestinal lymph node-like structure containing adenocarcinoma demonstrated endothelial venules, open marginal and intermediate sinuses, multiple polarized germinal centers, and partial capsule, consistent with an ectopic lymph node, also called a tertiary lymphoid organ. Twenty mesenteric lymph nodes were negative for carcinoma. The renal mass was a papillary renal cell carcinoma, Stage I. Intestinal tertiary lymphoid organs form in chronic immune activation and have variable structures ranging from simple B and T cell clusters to organized groups with high endothelial venules and lymphatic vessels. Encapsulation of tertiary lymphoid organs is rare, with some sources claiming this entity is never encapsulated. To our knowledge, this is the first report of small intestinal adenocarcinoma involving a submucosal encapsulated tertiary lymphoid organ, the prognostic significance of which is uncertain. We suggest increased awareness of intestinal tertiary lymphoid organs as an entity and further studies to delineate the effect their involvement by adenocarcinoma imparts on survival.

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“…Furthermore, small intestine cancer is often associated with Crohn's disease, celiac disease, polyps, and gastrointestinal polyposis syndrome. In addition, the better-known risk factors include inherited Peutz-Jeghers genetic syndrome, HNPCC (hereditary colorectal cancer without polyposis), or FAP (familial adenomatous polyposis) [29][30][31].…”

Section: Gastrointestinal Cancersmentioning

confidence: 99%

The Role of Pentraxin 3 in Gastrointestinal Cancers

Zajkowska,

Mroczko

2023

Cancers

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Gastrointestinal cancers have become a huge problem worldwide as the number of new cases continues to increase. Due to the growing need to explore new biomarkers and therapeutic targets for the detection and treatment of cancerous lesions, we sought to elucidate the role of Pentraxin-3 in the progression of cancerous lesions, as it is involved in the process of angiogenesis and inflammation. Statistically significant changes in the concentration of this parameter have emerged in many gastrointestinal cancer patients. Moreover, it is related to the advancement of cancer, as well as processes leading to the development of those changes. In the case of studies concerning tissue material, both increased and decreased tissue expression of the tested parameter were observed and were dependent on the type of cancer. In the case of cell lines, both human and animal, a significant increase in Pentraxin 3 gene expression was observed, which confirmed the changes observed at the protein level. In conclusion, it can be assumed that PTX3, both at the level of gene expression and protein concentrations, is highly useful in the detection of gastrointestinal cancers, and its use as a biomarker and/or therapeutic target may be useful in the future.

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Progress in the Treatment of Small Intestine Cancer

Cited by 7 publications

References 88 publications

Primary adenosquamous carcinoma of the duodenum: a rare case report with review of literature

Primary adenosquamous carcinoma of the duodenum: a rare case report with review of literature

Small Intestinal Adenocarcinoma Involving a Submucosal Ectopic Lymph Node: A Case Report

The Role of Pentraxin 3 in Gastrointestinal Cancers

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