Progress in the treatment of malignant ascites

Wang, Yiqiu; Sun, Yunting; Li, Xinyue; Yu, Xiaoli; Zhang, Keying; Liu, Jinglei; Tian, Qingchang; Zhang, Honghua; Du, Xiao; Wang, Shuling

doi:10.1016/j.critrevonc.2023.104237

Cited by 2 publications

(1 citation statement)

References 150 publications

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“…This process ultimately leads to peritoneal carcinomatosis [ 15 ]. When cancer cells disseminate widely in the peritoneum, a large volume of malignant ascites may develop, resulting from increased permeability due to the obstruction of lymphatic or blood vessels within the peritoneal cavity and secondary hypoalbuminemia [ 27 ]. Malignant ascites harbour elevated levels of immunosuppressive cytokines, further contributing to the refractory nature of CRC peritoneal metastasis [ 28 ].…”

Section: Crc Metastasismentioning

confidence: 99%

Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application

Fan,

Zhou,

Zhang

et al. 2024

Cell Commun Signal

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Metastasis poses a major challenge in colorectal cancer (CRC) treatment and remains a primary cause of mortality among patients with CRC. Recent investigations have elucidated the involvement of disrupted gut microbiota homeostasis in various facets of CRC metastasis, exerting a pivotal influence in shaping the metastatic microenvironment, triggering epithelial-mesenchymal transition (EMT), and so on. Moreover, therapeutic interventions targeting the gut microbiota demonstrate promise in enhancing the efficacy of conventional treatments for metastatic CRC (mCRC), presenting novel avenues for mCRC clinical management. Grounded in the “seed and soil” hypothesis, this review consolidates insights into the mechanisms by which imbalanced gut microbiota promotes mCRC and highlights recent strides in leveraging gut microbiota modulation for the clinical prevention and treatment of mCRC. Emphasis is placed on the considerable potential of manipulating gut microbiota within clinical settings for managing mCRC.

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Section: Crc Metastasismentioning

confidence: 99%

Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application

Fan,

Zhou,

Zhang

et al. 2024

Cell Commun Signal

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Preliminary Exploration of the Relationship between Tumor Microenvironment in Malignant Ascites and Patient Prognosis

Wang,

Cheng,

Wang

et al. 2024

Preprint

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Malignant ascites (MA) is a common complication of tumors which related to poor prognosis. With the deepening of the research on tumor microenvironment (TME), the influence of TME on prognosis is gradually understood. As a special TME, the relationship between MA and prognosis of patients need to be explored. 39 samples of MA in West China Hospital from 2018 to 2022 were collected for immunohistochemical (IHC) staining of CD4, CD8, CD11b, CD11c, CD16, CD19, CD163 and FOXP3. Through analyzing the relationship between the proportion of positive cells and the ascites-specific survival (ASS) of patients, immune cells infiltration score (ICIS) related to immune cell infiltration was established. Based on Kruskal-Wallis H test, the expression of CD8 in MA of different tumor types was significantly different (P = 0.014), the proportion of CD8 positive cells in biliary tract tumors is significantly higher than that in gastrointestinal (GI) tract tumors (P = 0.032). According to the multivariate cox regression analysis, only whether to receive chemotherapy was an independent prognostic risk factor. ICIS 1 (CD4, CD8, CD163, FOXP3) and ICIS2 (CD4, CD8, CD11b, CD11c, CD16, CD19, CD163, FOXP3) constructed according to immune cell infiltration can effectively predict the ASS of patients (ICIS1: High expression vs low expression, HR, 0.43, 95%CI (0.22–0.84), P = 0.0065; ICIS2: high vs. low expression, HR, 0.36, 95%CI (0.16–0.79), P = 0.0007). In general, the immune cells in MA are related to the survival of patients. The distribution model of immune cells based on TME has a good predictive value for the survival of patients.

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Progress in the treatment of malignant ascites

Cited by 2 publications

References 150 publications

Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application

Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application

Preliminary Exploration of the Relationship between Tumor Microenvironment in Malignant Ascites and Patient Prognosis

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