Abstract:Background: TAR DNA-binding protein 43 kDa (TDP-43) has been shown to play an important role in the development of neurodegenerative diseases, but the mechanism is still under study. Methods: By utilizing “TDP43”, “disease”, and “mechanism” as the keywords, 200 related studies were retrieved and downloaded from Pubmed database, including 60 articles. We summarized the progress in understanding TDP-43 mechanism over the past two years, focusing on disease systems and classification of the upstream and downstrea… Show more
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