Progress in the Extrapolation of Radiation Cataractogenesis Data Across Longer-Lived Mammalian Species

Cox, A.B.; Salmon, Y.L.; Lee, A. C.; Lett, J. T.; Williams, Gerald R.; Broerse, J.J.; Wagemaker, Gerard; Leavitt, Dennis D.

doi:10.1007/978-1-4615-2918-7_18

Cited by 6 publications

(6 citation statements)

References 12 publications

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“…Two sets of cataract examinations were performed on rhesus monkeys irradiated with photons and rescued with bone marrow transplant (BMT) or other means at The Radiobiological Institute, TNO, Rijswijk in The Netherlands; some data from the first set of evaluations may be found in reference (5). The funding for these measurements came from NATO, Colorado State University and the University of Leiden.…”

Section: Cataractogenesis and Other Optical Endpointsmentioning

confidence: 99%

Proton Radiation Studies

Cox¹

2002

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Section: Cataractogenesis and Other Optical Endpointsmentioning

confidence: 99%

Proton Radiation Studies

Cox¹

2002

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“…When male Fischer-344 rats were exposed to a single 2 Gy dose of 55 MeV protons at 10 weeks of age, no cataracts were seen until about 18 months of age in either the irradiated or control animals (Cox et al, 1993). From 18 months on, cataracts increased substantially in both the irradiated and control animals, and the difference between them appears to be insignificant.…”

Section: Cataractogenesismentioning

confidence: 99%

“…Lett et al (1991) have done an extensive study of cataractogenesis using the USAF/NASA monkeys, as well as a variety of other species (Cox et al, 1993) Of all the species they have studied, monkeys and rabbits demonstrated the most significant difference between controls and irradiated subjects. At doses of 2.5 Gy or less of protons (whole body radiation at an age of 2 years) there was no increase in cataract index until about 20 years after irradiation.…”

Section: Carcinogenesismentioning

confidence: 99%

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Modeling human risk: Cell & molecular biology in context

1997

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“…8 The geriatric rhesus monkeys used in this study were from the Brooks Air Force Base Delayed Effects Colony (DEC). 9 During the 1960s, NASA and the USAF conducted joint research investigating the effects of ionizing radiation for the manned space program in rhesus monkeys. The survivors of the acute radiation effects were placed in the DEC. Now ranging in age from 35 to 40 yr old they represent some of the oldest rhesus monkeys in captivity.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Optical Coherence Tomography Imaging of Cataracts With Histopathology

et al. 1999

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This paper presents a comparison of in vivo optical coherence tomography (OCT) captured cataract images to subsequent histopathological examination of the lenticular opacities. OCT imaging was performed on anesthetized Rhesus monkeys, known as the delayed effects colony (DEC), with documented cataracts. These monkeys were exposed to several types of radiation during the mid and late 1960s. The radiation and age related cataracts in these animals were closely monitored using a unique grading system developed specifically for the DEC. In addition to this system, a modified version of a common cataract grading scheme for use in humans was applied. Of the original 18 monkeys imaged, lenses were collected at necropsy from seven of these animals, processed, and compared to OCT images. Results showed a direct correlation between the vertical OCT images and the cataractous lesions seen on corresponding histopathologic sections of the lenses. Based on the images obtained and their corresponding documented comparison to histopathology, OCT showed tremendous potential to aid identification and characterization of cataracts. There can be artifactual problems with the images related to movement and shadows produced by opacities. However, with the advent of increased speed in imaging and multiplanar imaging, these disadvantages may easily be overcome. © 1999 Society of Photo-Optical Instrumentation Engineers.

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Progress in the Extrapolation of Radiation Cataractogenesis Data Across Longer-Lived Mammalian Species

Cited by 6 publications

References 12 publications

Proton Radiation Studies

Proton Radiation Studies

Modeling human risk: Cell & molecular biology in context

Comparison of Optical Coherence Tomography Imaging of Cataracts With Histopathology

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