Progress in the Asymmetric Synthesis of Statine and Its Analogs

Abstract

Statine and its analogs are special kind of β-hydroxy-γ-amino acids, which are usually core segments in many bioactive compounds. In this paper, several synthetic strategies are summarized.

Diastereoselective Synthesis and Conformational Analysis of (2R)- and (2S)-Fluorostatines: An Approach Based on Organocatalytic Fluorination of a Chiral Aldehyde

“… Such peptides usually act as protease inhibitors and hence hold great potential for the treatment of various diseases including cancer (cathepsin D), Alzheimer’s disease (cathepsin D, BACE, α-secretase), hypertension (renin), AIDS (HIV protease), and malaria (plasmepsins) . As a result, the synthesis of both natural statines and their analogues has been a subject of intense interest …”