Progress in Synthesis of 2-Substituted Benzothiazole Compounds

Zhang, Jun; Liu, Yafei; Zhang, Yurong; Hu, Liang; Han, Shiqing

doi:10.6023/cjoc202007036

Cited by 6 publications

(2 citation statements)

References 18 publications

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“…In the same period, an article review for the period from 2015 to 2020, relating to patents of pharmacological activities of BTs, was reported [73]. Even from the last past year until now, thirteen reviews about this topic have been reported in the literature [74][75][76][77][78][79][80][81][82][83][84][85].…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis and Biological Activities of (Thio)Urea Benzothiazole Derivatives

Mendieta-Wejebe

Rosales‐Hernández

Padilla‐Martínez

et al. 2023

IJMS

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(Thio)ureas ((T)Us) and benzothiazoles (BTs) each have demonstrated to have a great variety of biological activities. When these groups come together, the 2-(thio)ureabenzothizoles [(T)UBTs] are formed, improving the physicochemical as well as the biological properties, making these compounds very interesting in medicinal chemistry. Frentizole, bentaluron and methabenzthiazuron are examples of UBTs used for treatment of rheumatoid arthritis and as wood preservatives and herbicides in winter corn crops, respectively. With this antecedent, we recently reported a bibliographic review about the synthesis of this class of compounds, from the reaction of substituted 2-aminobenzothiazoles (ABTs) with iso(thio)cyanates, (thio)phosgenes, (thio)carbamoyl chlorides, 1,1’-(thio)carbonyldiimidazoles, and carbon disulfide. Herein, we prepared a bibliographic review about those features of design, chemical synthesis, and biological activities relating to (T)UBTs as potential therapeutic agents. This review is about synthetic methodologies generated from 1968 to the present day, highlighting the focus to transform (T)UBTs to compounds containing a range substituents, as illustrated with 37 schemes and 11 figures and concluded with 148 references. In this topic, the scientists dedicated to medicinal chemistry and pharmaceutical industry will find useful information for the design and synthesis of this interesting group of compounds with the aim of repurposing these compounds.

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Section: Introductionmentioning

confidence: 99%

Design, Synthesis and Biological Activities of (Thio)Urea Benzothiazole Derivatives

Mendieta-Wejebe

Rosales‐Hernández

Padilla‐Martínez

et al. 2023

IJMS

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“…Thus, new strategies for the high-atom-economic synthesis of the benzoxazole/benzothiazole framework are extremely desirable . As our continued efforts to exploit new carbon–heteroatom bond formation, herein, we report the first element sulfur-mediated oxidative cyclization to furnish benzoxazoles using the CC double bond as a one-carbon source (Scheme b). We also extended this strategy to construct a benzothiazole framework from 2-iodoaniline, alkenes, and elemental sulfur under the Cu(II)-catalyzed condition.…”

Section: Introductionmentioning

confidence: 99%