Progress in self-healing hydrogels and their applications in bone tissue engineering

Erezuma, Itsasne; Lukin, Izeia; Desimone, Martín Federico; Zhang, Yu Shrike; Dolatshahi‐Pirouz, Alireza; Orive, Gorka

doi:10.1016/j.bioadv.2022.213274

Cited by 18 publications

(10 citation statements)

References 84 publications

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“…The self-healing hydrogels are expected to restore to their initial structures after suffering from mechanical damage, thus maintaining the integrity of network structures and stability of the cell culture environment. 57,58 For cartilage protection and repair, the self-healing materials can retain the mechanical strength of the cartilage, reduce local friction, and promote regeneration of the damaged cartilage. 59,60 As displayed in Figure 4a, the self-healing mechanism of the hydrogels was primarily ascribed to the dynamic reversible Schiff base linkage.…”

Section: Rheological Properties and Compressionmentioning

confidence: 99%

Injectable, In Situ Self-cross-linking, Self-healing Poly(l-glutamic acid)/Polyethylene Glycol Hydrogels for Cartilage Tissue Engineering

Niu

Shi

et al. 2023

ACS Biomater. Sci. Eng.

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Injectable hydrogels have drawn much attention in the field of tissue engineering because of advantages such as simple operation, strong plasticity, and good biocompatibility and biodegradability. Herein, we propose the novel design of injectable hydrogels via a Schiff base cross-linking reaction between adipic dihydrazide (ADH)-modified poly(l-glutamic acid) (PLGA-ADH) and benzaldehyde-terminated poly(ethylene glycol) (PEG-CHO). The effects of the mass fraction and the molar ratio of −CHO/–NH2 on the gelation time, mechanical properties, equilibrium swelling, and in vitro degradation of the hydrogels were examined. The PLGA/PEG hydrogels cross-linked by dynamic Schiff base linkages exhibited good self-healing ability. Additionally, the PLGA/PEG hydrogels had good biocompatibility with bone marrow-derived mesenchymal stem cells (BMSCs) and could effectively support BMSC proliferation and deposition of glycosaminoglycans and upregulate the expression of cartilage-specific genes. In a rat cartilage defect model, PLGA/PEG hydrogels significantly promoted new cartilage formation. The results suggest the prospect of the PLGA/PEG hydrogels in cartilage tissue engineering.

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Section: Rheological Properties and Compressionmentioning

confidence: 99%

Injectable, In Situ Self-cross-linking, Self-healing Poly(l-glutamic acid)/Polyethylene Glycol Hydrogels for Cartilage Tissue Engineering

Niu

Shi

et al. 2023

ACS Biomater. Sci. Eng.

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“…The selection of covalent [20] and noncovalent [21] bonds as the base interactions for the formation of dynamic crosslinking hydrogels should not only be considered as an effective approach for both injectability and self-healing applications, but also as affecting the healing efficiency. Currently, hydrogel dressings with self-healing and injectable functions [22] have the ability of immediate reorganization and integration and the ability to mold to different shapes of wounds within a few seconds [23]. Hydrogel dressings can also carry various functional drugs and deliver them directly to the wound site [24].…”

Section: Introductionmentioning

confidence: 99%

Advances in Functional Hydrogel Wound Dressings: A Review

et al. 2023

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One of the most advanced, promising, and commercially viable research issues in the world of hydrogel dressing is gaining functionality to achieve improved therapeutic impact or even intelligent wound repair. In addition to the merits of ordinary hydrogel dressings, functional hydrogel dressings can adjust their chemical/physical properties to satisfy different wound types, carry out the corresponding reactions to actively create a healing environment conducive to wound repair, and can also control drug release to provide a long-lasting benefit. Although a lot of in-depth research has been conducted over the last few decades, very few studies have been properly summarized. In order to give researchers a basic blueprint for designing functional hydrogel dressings and to motivate them to develop ever-more intelligent wound dressings, we summarized the development of functional hydrogel dressings in recent years, as well as the current situation and future trends, in light of their preparation mechanisms and functional effects.

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“…Hydrogels are three-dimensional polymer networks with a high water uptake capacity used for biomedical applications. [1][2][3][4][5] A range of polymers, including chitosan, [6][7][8] cellulose, [9][10][11][12] and alginate, [2,13,22,23,[14][15][16][17][18][19][20][21] are commonly used for the preparation of hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Enhancing the Properties of Self‐Healing Gelatin Alginate Hydrogels by Hofmeister Mediated Electrostatic Effect

Das,

Majumdar

2023

ChemPhysChem

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The cross‐linker‐free hydrogels have gained attention due to their lack of need for chemically modified polymers, resulting in better biocompatibility. The hydrogel properties can be enhanced by altering physical forces such as electrostatics and H‐bonds. Tuning the physical interactions between polymers, salts, and plasticisers can unlock new horizons in material properties. This article examines four different salts and mixtures to determine their impact on gelatin‐alginate biomaterial design. Drug release, swelling, and rheological properties are represented using a 3‐D plot, and optimum samples are identified. It is concluded that kosmotropes yield better release and swelling results than chaotropes. The physical interactions of these salts with polymers are explained using DLS and FTIR/ATR studies, and these findings are corroborated with release, swelling, and rheological analyses. Another aspect of the biomaterial, self‐healing property, is also considered. A 3‐D plot is prepared using release kinetics, gel strength, and recovery percentage (three important factors for self‐healing hydrogels). Chaotropes are identified as better candidates for self‐healing behaviour. However, when considering gel strength, release, and self‐healing, kosmotropes are favourable. Hence, different salts can be selected based on the desired application for hydrogels. It is also concluded that electrostatic forces hinder the formation of H‐bonds between polymer chains.

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Progress in self-healing hydrogels and their applications in bone tissue engineering

Cited by 18 publications

References 84 publications

Injectable, In Situ Self-cross-linking, Self-healing Poly(l-glutamic acid)/Polyethylene Glycol Hydrogels for Cartilage Tissue Engineering

Injectable, In Situ Self-cross-linking, Self-healing Poly(l-glutamic acid)/Polyethylene Glycol Hydrogels for Cartilage Tissue Engineering

Advances in Functional Hydrogel Wound Dressings: A Review

Enhancing the Properties of Self‐Healing Gelatin Alginate Hydrogels by Hofmeister Mediated Electrostatic Effect

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